Germline MC1R variants and BRAF mutant melanoma

被引：9
|
作者：
Hacker, Elke [1 ]
Hayward, Nicholas K. [1 ]
机构：
[1] Queensland Inst Med Res, Oncogen Lab, Brisbane, Qld 4006, Australia
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2008年 / 128卷 / 10期
关键词：
D O I：
10.1038/jid.2008.236
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Recent studies have demonstrated that melanocortin-1 receptor (MC1R) variants increase the risk of melanomas harboring BRAF mutations. This finding provides insight into the relationship between host genotype and selection for somatic mutation type. Additional larger studies are required in diverse populations to further examine the interaction between MC1R and BRAF in different melanoma subtypes.
引用
收藏
页码：2354 / 2356
页数：4
相关论文
共 50 条
  • [21] MC1R variants and cutaneous melanoma risk in the Southern Brazil population
    Do Nascimento, C. R.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (09) : B2 - B2
  • [22] Melanoma disparity in Hawaii: Germline alterations of MC1R in a non-Caucasian population
    Morita, Shane Young
    Lum, Christopher A.
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [23] Inherited MC1R variants in patients with melanoma are associated with better survival in women
    Lira, F. E.
    Podlipnik, S.
    Potrony, M.
    Tell-Marti, G.
    Calbet-Llopart, N.
    Barreiro, A.
    Carrera, C.
    Malvehy, J.
    Puig, S.
    BRITISH JOURNAL OF DERMATOLOGY, 2020, 182 (01) : 138 - 146
  • [24] MC1R variants and melanoma risk: First study on Melan-Cohort
    Soufir, N.
    Miss, L. Bagait
    Miss, C. Oudin
    Wolkenstein, P.
    Descamps, V.
    Dupin, N.
    Lebbe, C.
    Basset-Seguin, N.
    Saiag, P.
    Grandchamp, B.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [25] Melanoma risk associated with MC1R gene variants in Latvia and the functional analysis of rare variants
    Ozola, Aija
    Azarjana, Kristine
    Donina, Simona
    Proboka, Guna
    Mandrika, Ilona
    Petrovska, Ramona
    Cema, Ingrida
    Heisele, Olita
    Engele, Ludmila
    Streinerte, Baiba
    Pjanova, Dace
    CANCER GENETICS, 2013, 206 (03) : 81 - 91
  • [26] Associations of phenotypic characteristics, MC1R variants, and prior amelanotic melanoma with incident amelanotic melanoma
    Vernali, S.
    Kanetsky, P. A.
    Orlow, I.
    Luo, L.
    Berwick, M.
    Thomas, N. E.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017, 137 (05) : S28 - S28
  • [27] MC1R CpG island regulates MC1R expression and is methylated in a subset of melanoma tumours
    Budden, Timothy
    Bowden, Nikola A.
    PIGMENT CELL & MELANOMA RESEARCH, 2019, 32 (02) : 320 - 325
  • [28] Detrimental effects of melanocortin-1 receptor (MC1R) variants on the clinical outcomes of BRAF V600 metastatic melanoma patients treated with BRAF inhibitors
    Guida, Michele
    Strippoli, Sabino
    Ferretta, Anna
    Bartolomeo, Nicola
    Porcelli, Letizia
    Maida, Immacolata
    Azzariti, Amalia
    Tommasi, Stefania
    Grieco, Claudia
    Guida, Stefania
    Albano, Anna
    Lorusso, Vito
    Guida, Gabriella
    PIGMENT CELL & MELANOMA RESEARCH, 2016, 29 (06) : 679 - 687
  • [29] GSTP1 and MC1R in melanoma susceptibility
    Sturm, R. A.
    BRITISH JOURNAL OF DERMATOLOGY, 2012, 166 (06) : 1155 - 1156
  • [30] MC1R variants as genetic markers of increased risk of melanoma in persons with protective phenotype
    Kanetsky, Peter
    Panossian, Saarene
    Elder, David
    Guerry, DuPont
    Ming, Michael
    Schuchter, Lynn
    Rebbeck, Timothy
    CANCER RESEARCH, 2009, 69
12345