Antimicrobial and antioxidant activity evaluation of tetrazolo[1,5-a] pyrimidines: A simple diisopropylammonium trifluoroacetate mediated synthesis

被引：35

作者：

Raju, Chandran ^{[1
]}

Madhaiyan, Kalaipriya ^{[2
]}

Uma, Ramakrishnan ^{[1
]}

Sridhar, Radhakrishnan ^{[2
]}

Ramakrishna, Seeram ^{[2
]}

机构：

[1] Univ Madras, Pachaiyappas Coll, Madras 600029, Tamil Nadu, India

[2] Natl Univ Singapore, NUSCNN Lab, Singapore 117548, Singapore

来源：

RSC ADVANCES | 2012年 / 2卷 / 31期

关键词：

RADICAL SCAVENGING ACTIVITIES; ONE-POT SYNTHESIS; EXTRACTS; CATALYST;

D O I：

10.1039/c2ra21330c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple, efficient and economic synthesis of tetrazolo[1,5-a]pyrimidine-6-carboxylates was accomplished by three-component reaction of beta-ketoesters with a mixture of aromatic aldehyde and 5-aminotetrazole using TFA:DIPEA (1 : 1) as the catalyst. The synthesized tetrazole compounds are evaluated for their antimicrobial and antioxidant activity.

引用

页码：11657 / 11663

页数：7

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