Antimicrobial and antioxidant activity evaluation of tetrazolo[1,5-a] pyrimidines: A simple diisopropylammonium trifluoroacetate mediated synthesis

被引：35
|
作者：
Raju, Chandran [1 ]
Madhaiyan, Kalaipriya [2 ]
Uma, Ramakrishnan [1 ]
Sridhar, Radhakrishnan [2 ]
Ramakrishna, Seeram [2 ]
机构：
[1] Univ Madras, Pachaiyappas Coll, Madras 600029, Tamil Nadu, India
[2] Natl Univ Singapore, NUSCNN Lab, Singapore 117548, Singapore
来源：
RSC ADVANCES | 2012年 / 2卷 / 31期
关键词：
RADICAL SCAVENGING ACTIVITIES; ONE-POT SYNTHESIS; EXTRACTS; CATALYST;
D O I：
10.1039/c2ra21330c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple, efficient and economic synthesis of tetrazolo[1,5-a]pyrimidine-6-carboxylates was accomplished by three-component reaction of beta-ketoesters with a mixture of aromatic aldehyde and 5-aminotetrazole using TFA:DIPEA (1 : 1) as the catalyst. The synthesized tetrazole compounds are evaluated for their antimicrobial and antioxidant activity.
引用
收藏
页码：11657 / 11663
页数：7
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