Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors

被引:39
|
作者
Barua, Sumit [1 ]
Kim, Jong Youl [1 ]
Kim, Jae Young [1 ]
Kim, Jae Hwan [4 ]
Lee, Jong Eun [1 ,2 ,3 ]
机构
[1] Yonsei Univ, Coll Med, Dept Anat, 50-1 Yonsei Ro, Seoul 03722, South Korea
[2] Yonsei Univ, Coll Med, Brain Korea PLUS Project Med Sci 21, 50 Yonsei Ro, Seoul 03722, South Korea
[3] Yonsei Univ, Coll Med, Brain Res Inst, 50 Yonsei Ro, Seoul 03722, South Korea
[4] Sungkyunkwan Univ, Inst Basic Sci, CNIR, Seoul, South Korea
基金
新加坡国家研究基金会;
关键词
Agmatine; Ion channels; Receptors; Neurodegenerative disease; Receptor blockade; NITRIC-OXIDE SYNTHASE; MUSCARINIC ACETYLCHOLINE-RECEPTORS; PROTEIN-COUPLED RECEPTORS; GATED CALCIUM-CHANNEL; CELL-DEATH; CEREBRAL-ISCHEMIA; BRAIN-INJURY; SYNAPTIC PLASTICITY; ENDOGENOUS AGMATINE; INTERNATIONAL-UNION;
D O I
10.1007/s11064-018-02712-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The central nervous system (CNS) is the most injury-prone part of the mammalian body. Any acute or chronic, central or peripheral neurological disorder is related to abnormal biochemical and electrical signals in the brain cells. As a result, ion channels and receptors that are abundant in the nervous system and control the electrical and biochemical environment of the CNS play a vital role in neurological disease. The N-methyl-d-aspartate receptor, 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl) propanoic acid receptor, kainate receptor, acetylcholine receptor, serotonin receptor, 2-adrenoreceptor, and acid-sensing ion channels are among the major channels and receptors known to be key components of pathophysiological events in the CNS. The primary amine agmatine, a neuromodulator synthesized in the brain by decarboxylation of l-arginine, can regulate ion channel cascades and receptors that are related to the major CNS disorders. In our previous studies, we established that agmatine was related to the regulation of cell differentiation, nitric oxide synthesis, and murine brain endothelial cell migration, relief of chronic pain, cerebral edema, and apoptotic cell death in experimental CNS disorders. In this review, we will focus on the pathophysiological aspects of the neurological disorders regulated by these ion channels and receptors, and their interaction with agmatine in CNS injury.
引用
收藏
页码:735 / 750
页数:16
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