Mitochondrial ion channels as therapeutic targets

被引:39
|
作者
Peixoto, Pablo M. [1 ]
Ryu, Shin-Young [1 ]
Kinnally, Kathleen W. [1 ]
机构
[1] NYU, Coll Dent, New York, NY 10010 USA
基金
美国国家卫生研究院;
关键词
Mitochondrial ion channels; Patch clamp; Mitochondrial disease; Therapy; APOPTOSIS-INDUCED CHANNEL; DEPENDENT ANION CHANNELS; VOLTAGE-GATED CHANNEL; PERMEABILITY TRANSITION; OUTER-MEMBRANE; INNER MEMBRANE; CYTOCHROME-C; PROTEIN TRANSLOCATION; CONDUCTANCE CHANNEL; PHOSPHATE CARRIER;
D O I
10.1016/j.febslet.2010.02.046
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The study of mitochondrial ion channels changed our perception of these double-wrapped organelles from being just the power house of a cell to the guardian of a cell's fate. Mitochondria communicate with the cell through these special channels. Most of the time, the message is encoded by ion flow across the mitochondrial outer and inner membranes. Potassium, sodium, calcium, protons, nucleotides, and proteins traverse the mitochondrial membranes in an exquisitely regulated manner to control a myriad of processes, from respiration and mitochondrial morphology to cell proliferation and cell death. This review is an update on both well established and putative mitochondrial channels regarding their composition, function, regulation, and therapeutic potential. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:2142 / 2152
页数:11
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