PI3Kδ/γ Inhibitor Duvelisib Modulates Inflammatory Profile in Severe COVID-19 Patients: Results from a Randomized Placebo-Controlled Phase 2 Study

被引：0

作者：

Zhang, Hanwen ^{[1
]}

Wang, Shuhua ^{[1
]}

Rupji, Manali ^{[2
]}

Wu, Chenxi ^{[3
]}

Chandrasekaran, Sanjay ^{[4
]}

Funk, Christopher R. ^{[1
]}

King, Patrick J. ^{[5
]}

Kollipara, Saketh ^{[6
]}

Rao, Ishani ^{[6
]}

Ayanru, Esohe ^{[6
]}

Duffy, Julia ^{[7
]}

Kaplow, Roberta ^{[7
]}

Abousaud, Aseala ^{[8
]}

Mehta, Aneesh ^{[9
]}

Roback, John D. ^{[5
]}

Kalman, Daniel ^{[5
]}

Lyon, G. Marshall, III ^{[9
]}

Caridi-Scheible, Mark ^{[10
]}

Bisson, Gregory ^{[11
]}

Liu, Yuan ^{[2
]}

Coma, Silvia ^{[12
]}

Pachter, Jonathan A. ^{[12
]}

Giver, Cynthia R. ^{[1
]}

Waller, Edmund K. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA

[2] Emory Univ, Winship Canc Inst, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA

[3] Emory Univ, Sch Med, Dept Radiol & Imaging Sci, Atlanta, GA 30322 USA

[4] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[5] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[6] Emory Univ, Atlanta, GA 30322 USA

[7] Emory Univ Hosp, Emory Healthcare, 1364 Clifton Rd NE, Atlanta, GA 30322 USA

[8] Emory Healthcare, Atlanta, GA USA

[9] Emory Univ, Sch Med, Dept Infect Dis, Atlanta, GA 30322 USA

[10] Emory Univ, Sch Med, Crit Care Med, Atlanta, GA 30322 USA

[11] Univ Penn, Perelman Sch Med, Div Infect Dis, Dept Med, Philadelphia, PA 19104 USA

[12] Verastem Oncol, Needham, MA USA

来源：

BLOOD | 2022年 / 140卷

关键词：

D O I：

10.1182/blood-2022-165567

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：11187 / 11189

页数：3

共 50 条

[21] Ensitrelvir for the Treatment of Nonhospitalized Adults with COVID-19: Results from the SCORPIO-HR, Phase 3, Randomized, Double-blind, Placebo-Controlled Trial
Luetkemeyer, Anne F.
Chew, Kara W.
Lacey, Stuart
Hughes, Michael D.
Harrison, Linda J.
Daar, Eric S.
Eron, Joseph
Fletcher, Courtney V.
Greninger, Alexander L.
Hessinger, Diane
Li, Jonathan Z.
Mailhot, David
Wohl, David
Chayakulkeeree, Methee
Accini Mendoza, Jose Luis
Elistratova, Polina
Makinde, Oluwaseun
Morgan, Gareth
Portsmouth, Simon
Uehara, Takeki
Smith, Davey
Currier, Judith S.
CLINICAL INFECTIOUS DISEASES, 2025,
[22] Molnupiravir for the treatment of COVID-19 in immunocompromised participants: efficacy, safety, and virology results from the phase 3 randomized, placebo-controlled MOVe-OUT trial
Johnson, Matthew G.
Strizki, Julie M.
Brown, Michelle L.
Wan, Hong
Shamsuddin, Hala H.
Ramgopal, Moti
Florescu, Diana F.
Delobel, Pierre
Khaertynova, Ilsiyar
Flores, Jose F.
Fouche, Leon F.
Chang, Shan-Chwen
Williams-Diaz, Angela
Du, Jiejun
Grobler, Jay A.
Paschke, Amanda
De Anda, Carisa
INFECTION, 2023, 51 (05) : 1273 - 1284
[23] Molnupiravir for the treatment of COVID-19 in immunocompromised participants: efficacy, safety, and virology results from the phase 3 randomized, placebo-controlled MOVe-OUT trial
Matthew G. Johnson
Julie M. Strizki
Michelle L. Brown
Hong Wan
Hala H. Shamsuddin
Moti Ramgopal
Diana F. Florescu
Pierre Delobel
Ilsiyar Khaertynova
José F. Flores
Leon F. Fouche
Shan-Chwen Chang
Angela Williams-Diaz
Jiejun Du
Jay A. Grobler
Amanda Paschke
Carisa De Anda
Infection, 2023, 51 : 1273 - 1284
[24] Efficacy and safety of guselkumab in patients with active lupus nephritis: results from a phase 2, randomized, placebo-controlled study
Anders, Hans-Joachim
Chan, Tak Mao
Sanchez-Guerrero, Jorge
Wofsy, David
Bensley, Karen
Kim, Lilianne
Lo, Kim Hung
Shu, Cathye
Shao, Jie
Karyekar, Chetan S.
Diamond, Betty
RHEUMATOLOGY, 2024,
[25] Safety and Efficacy of Vidofludimus Calcium in Patients Hospitalized with COVID-19: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial
Vehreschild, Maria J. G. T.
Atanasov, Petar
Yurko, Kateryna
Oancea, Cristian
Popov, Georgi
Smesnoi, Valentina
Placinta, Gheorghe
Kohlhof, Hella
Vitt, Daniel
Peelen, Evelyn
Mihajlovic, Jelena
Muehler, Andreas R.
INFECTIOUS DISEASES AND THERAPY, 2022, 11 (06) : 2159 - 2176
[26] Safety and Efficacy of Vidofludimus Calcium in Patients Hospitalized with COVID-19: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial
Maria J. G. T. Vehreschild
Petar Atanasov
Kateryna Yurko
Cristian Oancea
Georgi Popov
Valentina Smesnoi
Gheorghe Placinta
Hella Kohlhof
Daniel Vitt
Evelyn Peelen
Jelena Mihajlović
Andreas R. Muehler
Infectious Diseases and Therapy, 2022, 11 : 2159 - 2176
[27] Guselkumab Modulates Differentially Expressed Genes in Blood of Patients With Psoriatic Arthritis: Results from Two Phase 3, Randomized, Placebo-Controlled Trials
Siebert, Stefan
Sweet, Kristen M.
Ritchlin, Christopher T.
Hsia, Elizabeth C.
Kollmeier, Alexa P.
Xu, Xie L.
Seridi, Loqmane
Song, Qingxuan
Gao, Sheng
Chen, Warner
Miron, Michelle
ACR OPEN RHEUMATOLOGY, 2023, 5 (09) : 490 - 498
[28] Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trial
Guylaine Labro
Florence Tubach
Lisa Belin
Jean-Louis Dubost
David Osman
Grégoire Muller
Jean-Pierre Quenot
Daniel Da Silva
Jonathan Zarka
Matthieu Turpin
Julien Mayaux
Christian Lamer
Denis Doyen
Guillaume Chevrel
Gaétan Plantefeve
Sophie Demeret
Gaël Piton
Cyril Manzon
Evelina Ochin
Raphael Gaillard
Bertrand Dautzenberg
Mathieu Baldacini
Said Lebbah
Makoto Miyara
Marc Pineton de Chambrun
Zahir Amoura
Alain Combes
Intensive Care Medicine, 2022, 48 : 876 - 887
[29] Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trial
Labro, Guylaine
Tubach, Florence
Belin, Lisa
Dubost, Jean-Louis
Osman, David
Muller, Gregoire
Quenot, Jean-Pierre
Da Silva, Daniel
Zarka, Jonathan
Turpin, Matthieu
Mayaux, Julien
Lamer, Christian
Doyen, Denis
Chevrel, Guillaume
Plantefeve, Gaetan
Demeret, Sophie
Piton, Gael
Manzon, Cyril
Ochin, Evelina
Gaillard, Raphael
Dautzenberg, Bertrand
Baldacini, Mathieu
Lebbah, Said
Miyara, Makoto
de Chambrun, Marc Pineton
Amoura, Zahir
Combes, Alain
INTENSIVE CARE MEDICINE, 2022, 48 (07) : 876 - 887
[30] A randomized, placebo-controlled pilot study of upamostat, a host-directed serine protease inhibitor, for outpatient treatment of COVID-19
Plasse, Terry F.
Delgado, Belkis
Potts, Jeffrey
Abramson, Danielle
Fehrmann, Clara
Fathi, Reza
McComsey, Grace A.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2023, 128 : 148 - 156

← 1 2 3 4 5 →