Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis

被引：13
|
作者：
Osame, Keiichiro [1 ]
Takahashi, Yoshihiko [1 ]
Takasawa, Hirofumi [1 ]
Watanabe, Shigeru [2 ]
Kishimoto, Miyako [1 ]
Yasuda, Kazuki [1 ]
Kaburagi, Yasushi [1 ]
Nakanishi, Koji [2 ]
Kajio, Hiroshi [1 ]
Noda, Mitsuhiko [1 ]
机构：
[1] Int Med Ctr Japan, Dept Endocrinol & Metab, Tokyo, Japan
[2] Toranomon Gen Hosp, Dept Endocrinol & Metab, Tokyo, Japan
来源：
INTERNAL MEDICINE | 2007年 / 46卷 / 12期
关键词：
diabetes; cytomegalovirus; ketoacidosis; GAD65;
D O I：
10.2169/internalmedicine.46.6395
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report the case of a 59-year-old woman who developed rapid-onset type 1 diabetes associated with a marked increase in anti-glutamic acid decarboxylase antibody titer (317.5 U/ml), mild increase in HbA1c level (6.8%), diabetic ketoacidosis, and cytomegalovirus enterocolitis. She was a heterozygote for HLA class II DRB1* 0901-DQA1* 03-DQB1* 0303, and she had HLA class I A24, which may have contributed to the rapid beta cell destruction. Based on the putative molecular mimicry of GAD65 by cytomegalovirus antigen, we hypothesize that the type 1 diabetes in this case was associated with cytomegalovirus infection.
引用
收藏
页码：873 / 877
页数：5
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