Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis

被引：13

作者：

Osame, Keiichiro ^{[1
]}

Takahashi, Yoshihiko ^{[1
]}

Takasawa, Hirofumi ^{[1
]}

Watanabe, Shigeru ^{[2
]}

Kishimoto, Miyako ^{[1
]}

Yasuda, Kazuki ^{[1
]}

Kaburagi, Yasushi ^{[1
]}

Nakanishi, Koji ^{[2
]}

Kajio, Hiroshi ^{[1
]}

Noda, Mitsuhiko ^{[1
]}

机构：

[1] Int Med Ctr Japan, Dept Endocrinol & Metab, Tokyo, Japan

[2] Toranomon Gen Hosp, Dept Endocrinol & Metab, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2007年 / 46卷 / 12期

关键词：

diabetes; cytomegalovirus; ketoacidosis; GAD65;

D O I：

10.2169/internalmedicine.46.6395

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the case of a 59-year-old woman who developed rapid-onset type 1 diabetes associated with a marked increase in anti-glutamic acid decarboxylase antibody titer (317.5 U/ml), mild increase in HbA1c level (6.8%), diabetic ketoacidosis, and cytomegalovirus enterocolitis. She was a heterozygote for HLA class II DRB1* 0901-DQA1* 03-DQB1* 0303, and she had HLA class I A24, which may have contributed to the rapid beta cell destruction. Based on the putative molecular mimicry of GAD65 by cytomegalovirus antigen, we hypothesize that the type 1 diabetes in this case was associated with cytomegalovirus infection.

引用

页码：873 / 877

页数：5

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