Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis

被引：13

作者：

Osame, Keiichiro ^{[1
]}

Takahashi, Yoshihiko ^{[1
]}

Takasawa, Hirofumi ^{[1
]}

Watanabe, Shigeru ^{[2
]}

Kishimoto, Miyako ^{[1
]}

Yasuda, Kazuki ^{[1
]}

Kaburagi, Yasushi ^{[1
]}

Nakanishi, Koji ^{[2
]}

Kajio, Hiroshi ^{[1
]}

Noda, Mitsuhiko ^{[1
]}

机构：

[1] Int Med Ctr Japan, Dept Endocrinol & Metab, Tokyo, Japan

[2] Toranomon Gen Hosp, Dept Endocrinol & Metab, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2007年 / 46卷 / 12期

关键词：

diabetes; cytomegalovirus; ketoacidosis; GAD65;

D O I：

10.2169/internalmedicine.46.6395

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the case of a 59-year-old woman who developed rapid-onset type 1 diabetes associated with a marked increase in anti-glutamic acid decarboxylase antibody titer (317.5 U/ml), mild increase in HbA1c level (6.8%), diabetic ketoacidosis, and cytomegalovirus enterocolitis. She was a heterozygote for HLA class II DRB1* 0901-DQA1* 03-DQB1* 0303, and she had HLA class I A24, which may have contributed to the rapid beta cell destruction. Based on the putative molecular mimicry of GAD65 by cytomegalovirus antigen, we hypothesize that the type 1 diabetes in this case was associated with cytomegalovirus infection.

引用

页码：873 / 877

页数：5

共 50 条

[1] Association of HLA-DQ genotype in autoantibody-negative and rapid-onset type 1 diabetes
Tanaka, S
Kobayashi, T
Nakanishi, K
Koyama, R
Okubo, M
Murase, T
Odawara, M
Inoko, H
DIABETES CARE, 2002, 25 (12) : 2302 - 2307
[2] Rapid-onset type 1 diabetes with pancreatic exocrine dysfunction.
Lernmark, Å
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (05): : 344 - 345
[3] Distinct Islet Autoantibody Profiles in Hispanic Youth at Type 1 Diabetes Onset
Simmons, Kimber M.
Vigers, Timothy B.
Pyle, Laura
Youngkin, Erin M.
Baschal, Erin E.
Mcdaniel, Kristen
Yu, Liping
Michels, Aaron W.
DIABETES, 2022, 71
[4] Rapid-onset type 1 diabetes mellitus without pancreatic exocrine dysfunction
Yamazaki, M
Hayashi, T
ANNALS OF INTERNAL MEDICINE, 2002, 137 (02) : 145 - 146
[5] Significance and clinical characteristics of rapid-onset type 1 diabetes mellitus in Japanese
Kusaka, I
Nagasaka, S
Kawakami, A
Saito, T
Nakamura, T
Rokkaku, K
Higashiyama, M
Ishikawa, SE
Saito, T
DIABETES, 2001, 50 : A97 - A97
[6] Stratifying risk for onset of type 1 diabetes using islet autoantibody trajectory clustering
Mistry, Sejal
Gouripeddi, Ramkiran
Raman, Vandana
Facelli, Julio C.
DIABETOLOGIA, 2023, 66 (03) : 520 - 534
[7] Stratifying risk for onset of type 1 diabetes using islet autoantibody trajectory clustering
Sejal Mistry
Ramkiran Gouripeddi
Vandana Raman
Julio C. Facelli
Diabetologia, 2023, 66 : 520 - 534
[8] Rapid-onset diabetic nephropathy in type II diabetes mellitus
Dillon, JJ
Sedmak, DD
Cosio, FG
RENAL FAILURE, 1997, 19 (06) : 819 - 822
[9] RAPID-ONSET DIABETES: AN OMINOUS SIGN?
Cromer, Sara Jane
JOURNAL OF GENERAL INTERNAL MEDICINE, 2017, 32 : S575 - S575
[10] The relationship between islet autoantibody status and the genetic risk of type 1 diabetes in adult-onset type 1 diabetes
Nicholas J. Thomas
Helen C. Walkey
Akaal Kaur
Shivani Misra
Nick S. Oliver
Kevin Colclough
Michael N. Weedon
Desmond G. Johnston
Andrew T. Hattersley
Kashyap A. Patel
Diabetologia, 2023, 66 : 310 - 320

← 1 2 3 4 5 →