Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders

被引：12

作者：

Moraca, Federica ^{[1
,2
]}

Marzano, Simona ^{[1
]}

D'Amico, Francesco ^{[3
]}

Lupia, Antonio ^{[1
,2
]}

Di Fonzo, Silvia ^{[3
]}

Vertecchi, Eleonora ^{[4
]}

Salvati, Erica ^{[4
]}

Di Porzio, Anna ^{[1
]}

Catalanotti, Bruno ^{[1
]}

Randazzo, Antonio ^{[1
]}

Pagano, Bruno ^{[1
]}

Amato, Jussara ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy

[2] Univ Magna Groecia Catanzaro, Net4Sci Srl, I-88100 Catanzaro, Italy

[3] Elettra Sincrotrone Trieste SCPA, Sci Pk, I-34149 Trieste, Italy

[4] CNR, Inst Mol Biol & Pathol, Via Apuli 4, I-00185 Rome, Italy

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 85期

关键词：

COVID-19; DNA;

D O I：

10.1039/d2cc03135c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such RNA structures. Further in silico and in vitro assays identified three drugs as emerging SARS-CoV-2 RNA G-quadruplex binders.

引用

页码：11913 / 11916

页数：5

共 50 条

[31] In Silico Screening of Potential Spike Glycoprotein Inhibitors of SARS-CoV-2 with Drug Repurposing Strategy
WEI Tian-zi
WANG Hao
WU Xue-qing
LU Yi
GUAN Sheng-hui
DONG Feng-quan
DONG Chen-le
ZHU Gu-li
BAO Yu-zhou
ZHANG Jian
WANG Guan-yu
LI Hai-ying
Chinese Journal of Integrative Medicine , 2020, (09) : 663 - 669
[32] An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors
Alfonso Trezza
Daniele Iovinelli
Annalisa Santucci
Filippo Prischi
Ottavia Spiga
Scientific Reports, 10
[33] An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors
Trezza, Alfonso
Iovinelli, Daniele
Santucci, Annalisa
Prischi, Filippo
Spiga, Ottavia
SCIENTIFIC REPORTS, 2020, 10 (01)
[34] In Silico Screening of Potential Spike Glycoprotein Inhibitors of SARS-CoV-2 with Drug Repurposing Strategy
WEI Tianzi
WANG Hao
WU Xueqing
LU Yi
GUAN Shenghui
DONG Fengquan
DONG Chenle
ZHU Guli
BAO Yuzhou
ZHANG Jian
WANG Guanyu
LI Haiying
Chinese Journal of Integrative Medicine, 2020, 26 (09) : 663 - 669
[35] In Silico Screening of Potential Spike Glycoprotein Inhibitors of SARS-CoV-2 with Drug Repurposing Strategy
Tian-zi Wei
Hao Wang
Xue-qing Wu
Yi Lu
Sheng-hui Guan
Feng-quan Dong
Chen-le Dong
Gu-li Zhu
Yu-zhou Bao
Jian Zhang
Guan-yu Wang
Hai-ying Li
Chinese Journal of Integrative Medicine, 2020, 26 : 663 - 669
[36] A Rolling Circle-Amplified G-Quadruplex/Hemin DNAzyme for Chemiluminescence Immunoassay of the SARS-CoV-2 Protein
Zhang, Rui
Wu, Jie
Ao, Hang
Fu, Jinling
Qiao, Bin
Wu, Qiang
Ju, Huangxian
ANALYTICAL CHEMISTRY, 2021, 93 (28) : 9933 - 9938
[37] Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
Tummino, Tia A.
Rezelj, Veronica V.
Fischer, Benoit
Fischer, Audrey
O'Meara, Matthew J.
Monel, Blandine
Vallet, Thomas
White, Kris M.
Zhang, Ziyang
Alon, Assaf
Schadt, Heiko
O'Donnell, Henry R.
Lyu, Jiankun
Rosales, Romel
McGovern, Briana L.
Rathnasinghe, Raveen
Jangra, Sonia
Schotsaert, Michael
Galarneau, Jean-Rene
Krogan, Nevan J.
Urban, Laszlo
Shokat, Kevan M.
Kruse, Andrew C.
Garcia-Sastre, Adolfo
Schwartz, Olivier
Moretti, Francesca
Vignuzzi, Marco
Pognan, Francois
Shoichet, Brian K.
SCIENCE, 2021, 373 (6554) : 541 - +
[38] Way2drug platform - ligand-based approach to drug repurposing
Druzhilovskiy, Dmitry
Rudik, Anastasiya
Filimonov, Dmitry
Sastry, G. Narahari
Poroikov, Vladimir
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
[39] TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
De Magis, Alessio
Schult, Philipp
Schoenleber, Antonia
Linke, Rebecca
Ludwig, Kerstin U.
Kuemmerer, Beate M.
Paeschke, Katrin
BMC BIOLOGY, 2024, 22 (01)
[40] TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Alessio De Magis
Philipp Schult
Antonia Schönleber
Rebecca Linke
Kerstin U. Ludwig
Beate M. Kümmerer
Katrin Paeschke
BMC Biology, 22

← 1 2 3 4 5 →