Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders

被引：12

作者：

Moraca, Federica ^{[1
,2
]}

Marzano, Simona ^{[1
]}

D'Amico, Francesco ^{[3
]}

Lupia, Antonio ^{[1
,2
]}

Di Fonzo, Silvia ^{[3
]}

Vertecchi, Eleonora ^{[4
]}

Salvati, Erica ^{[4
]}

Di Porzio, Anna ^{[1
]}

Catalanotti, Bruno ^{[1
]}

Randazzo, Antonio ^{[1
]}

Pagano, Bruno ^{[1
]}

Amato, Jussara ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy

[2] Univ Magna Groecia Catanzaro, Net4Sci Srl, I-88100 Catanzaro, Italy

[3] Elettra Sincrotrone Trieste SCPA, Sci Pk, I-34149 Trieste, Italy

[4] CNR, Inst Mol Biol & Pathol, Via Apuli 4, I-00185 Rome, Italy

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 85期

关键词：

COVID-19; DNA;

D O I：

10.1039/d2cc03135c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such RNA structures. Further in silico and in vitro assays identified three drugs as emerging SARS-CoV-2 RNA G-quadruplex binders.

引用

页码：11913 / 11916

页数：5

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