Impact of Laparoscopy to Assess Resectability in Stage IIIC Epithelial Ovarian, Tubal and Peritoneal Cancer Patients

被引:3
|
作者
Luis Sanchez-Iglesias, Jose [1 ]
Perez-Benavente, Assumpcio [1 ]
Correa-Paris, Alejandro [2 ,3 ]
Fernandez de Vega, Avier De la Torre [1 ]
Carbonell Socias, Melchor [1 ]
Gil-Moreno, Antonio [1 ,3 ]
机构
[1] Hosp Univ Vall dHebron, Dept Obstet & Gynecol, Unit Gynecol Oncol, Barcelona, Spain
[2] ICS, Primary Care AP Barcelona, Sexual & Reprod Hlth Care ASSIR, Barcelona, Spain
[3] UAB, Dept Pediat Obstet & Ginecol & Med Prevent, Barcelona, Spain
关键词
Ovarian epithelial cancer; Laparoscopy; Overall survival; Disease-free survival; Neoplasm staging; INTERVAL DEBULKING SURGERY; PRIMARY CYTOREDUCTIVE SURGERY; NEOADJUVANT CHEMOTHERAPY; SURVIVAL; CARCINOMA; OUTCOMES; TRIALS; TIME;
D O I
10.1159/000493794
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aims: To evaluate overall survival (OS) and progression-free survival (PFS) in patients with stage IIIC epithelial ovarian, tubal and peritoneal cancer (EOC) who underwent a laparoscopy to assess surgical resectability prior to Primary Debulking Surgery (PDS) or Interval Debulking Surgery (IDS). Methods: Retrospective cohort study that included all women with stage IIIC EOC treated at our center between 2000 and 2010. Patients were classified in groups: PDS, neoadjuvant chemotherapy (NACT) with IDS, NACT without IDS; and then sub-classified based on residual tumor (RT). A laparoscopy to assess resectability was performed before PDS and IDS. Results: Among 111 patients included, 66 underwent PDS, and 45 were treated with NACT, 80% of them receiving subsequent IDS. OS was 75.6 months in the PDS group, and 52.8 months for IDS group (p = 0.100); the PFS was 30 months and 19.2 months respectively (p = 0.049). Median OS was 104.4 and 52.8 months for patients with optimal cytoreduction (RT = 0) in the PDS and IDS group respectively (p < 0.05). Laparoscopy did not modify the preoperative consideration for PDS; however, 9 laparotomies were avoided based on laparoscopic findings after NACT. Conclusion: Laparoscopy for the assessment of surgical resectability in stage IIIC EOC has no impact on survival; but it still could be useful for the reduction of unnecessary laparotomies after NACT. (C) 2018 S. Karger AG, Basel
引用
收藏
页码:259 / 267
页数:9
相关论文
共 50 条
  • [41] Impact of the Time Interval from Neoadjuvant Chemotherapy to Surgery in Primary Ovarian, Tubal, and Peritoneal Cancer Patients
    Chen, Ming
    Chen, Zhanpeng
    Xu, Manman
    Liu, Duo
    Liu, Tianyu
    He, Mian
    Yao, Shuzhong
    JOURNAL OF CANCER, 2018, 9 (21): : 4087 - 4091
  • [42] The role of laparoscopy in epithelial ovarian cancer
    Audifred-Salomon, J.
    Martinez-Madrigal, M.
    GACETA MEXICANA DE ONCOLOGIA, 2009, 8 (06): : 232 - 237
  • [43] Second primary cancer after primary peritoneal, epithelial ovarian, and fallopian tubal cancer: a retrospective study
    Lim, Myong Cheol
    Won, Young-Joo
    Lim, Jiwon
    Salehi, Tahereh
    Yoo, Chong Woo
    Bristow, Robert E.
    BMC CANCER, 2018, 18
  • [44] Second primary cancer after primary peritoneal, epithelial ovarian, and fallopian tubal cancer: a retrospective study
    Myong Cheol Lim
    Young-Joo Won
    Jiwon Lim
    Tahereh Salehi
    Chong Woo Yoo
    Robert E. Bristow
    BMC Cancer, 18
  • [45] A prospective study on the diagnostic pathway of patients with stage IIIC-IV ovarian cancer: Can laparoscopy improve CT-scan?
    Campanile, R. Garruto
    Majd, H. Soleymani
    Casarin, J.
    Morotti, M.
    Tozzi, R.
    GYNECOLOGIC ONCOLOGY, 2018, 149 : 237 - 237
  • [46] NEOADJUVANT CHEMOTHERAPY IN THE COMPLEX TREATMENT OF PATIENTS WITH STAGE IIIC - IV OVARIAN CANCER
    Kryzhanivska, Anna
    Djakiv, Iryna
    Hrytsyk, Roman
    ANTICANCER RESEARCH, 2023, 43 (07) : 3377 - 3377
  • [47] The Impact of Peritoneal Metastases in Epithelial Ovarian Cancer With Positive Nodes
    Pereira, Augusto
    Magrina, Javier F.
    Magtibay, Paul M.
    Perez-Medina, Tirso
    Fernandez, Ana
    Peregrin, Irene
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2011, 21 (08) : 1375 - 1379
  • [48] Prognostic factor on optimal debulking surgery by maximum effort for stage IIIC epithelial ovarian cancer
    Terauchi, Fumitoshi
    Nishi, Hirotaka
    Moritake, Tetsuya
    Kobayashi, Yukari
    Nagashima, Takeo
    Onodera, Takamoto
    Fujito, Atsuya
    Nakayama, Daiei
    Isaka, Keiichi
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2009, 35 (02) : 315 - 319
  • [49] Survival impact of complete cytoreductive surgery in the primary management of FIGO stage IIIC, high-grade, epithelial ovarian cancer
    Santillan, A.
    Tanner, E., III
    Guile, M.
    Mulla, Z.
    Diaz-Montes, T. P.
    Giuntoli, R. L., II
    Bristow, R. E.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [50] Stage IIIC Ovarian Cancer-A Heterogeneous Group of Patients with Different Prognosis
    Bakkar, R.
    Gershenson, D.
    Silva, E.
    MODERN PATHOLOGY, 2011, 24 : 236A - 237A