Impact of Laparoscopy to Assess Resectability in Stage IIIC Epithelial Ovarian, Tubal and Peritoneal Cancer Patients

被引:3
|
作者
Luis Sanchez-Iglesias, Jose [1 ]
Perez-Benavente, Assumpcio [1 ]
Correa-Paris, Alejandro [2 ,3 ]
Fernandez de Vega, Avier De la Torre [1 ]
Carbonell Socias, Melchor [1 ]
Gil-Moreno, Antonio [1 ,3 ]
机构
[1] Hosp Univ Vall dHebron, Dept Obstet & Gynecol, Unit Gynecol Oncol, Barcelona, Spain
[2] ICS, Primary Care AP Barcelona, Sexual & Reprod Hlth Care ASSIR, Barcelona, Spain
[3] UAB, Dept Pediat Obstet & Ginecol & Med Prevent, Barcelona, Spain
关键词
Ovarian epithelial cancer; Laparoscopy; Overall survival; Disease-free survival; Neoplasm staging; INTERVAL DEBULKING SURGERY; PRIMARY CYTOREDUCTIVE SURGERY; NEOADJUVANT CHEMOTHERAPY; SURVIVAL; CARCINOMA; OUTCOMES; TRIALS; TIME;
D O I
10.1159/000493794
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aims: To evaluate overall survival (OS) and progression-free survival (PFS) in patients with stage IIIC epithelial ovarian, tubal and peritoneal cancer (EOC) who underwent a laparoscopy to assess surgical resectability prior to Primary Debulking Surgery (PDS) or Interval Debulking Surgery (IDS). Methods: Retrospective cohort study that included all women with stage IIIC EOC treated at our center between 2000 and 2010. Patients were classified in groups: PDS, neoadjuvant chemotherapy (NACT) with IDS, NACT without IDS; and then sub-classified based on residual tumor (RT). A laparoscopy to assess resectability was performed before PDS and IDS. Results: Among 111 patients included, 66 underwent PDS, and 45 were treated with NACT, 80% of them receiving subsequent IDS. OS was 75.6 months in the PDS group, and 52.8 months for IDS group (p = 0.100); the PFS was 30 months and 19.2 months respectively (p = 0.049). Median OS was 104.4 and 52.8 months for patients with optimal cytoreduction (RT = 0) in the PDS and IDS group respectively (p < 0.05). Laparoscopy did not modify the preoperative consideration for PDS; however, 9 laparotomies were avoided based on laparoscopic findings after NACT. Conclusion: Laparoscopy for the assessment of surgical resectability in stage IIIC EOC has no impact on survival; but it still could be useful for the reduction of unnecessary laparotomies after NACT. (C) 2018 S. Karger AG, Basel
引用
收藏
页码:259 / 267
页数:9
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