Improvement of the HIV fusion inhibitor C34 activity by membrane anchoring and enhanced exposure

被引：0
|
作者：
Augusto, M. T. [1 ]
Hollmann, A. [1 ]
Castanho, M. A. R. B. [1 ]
Pessi, A. [2 ]
Santos, N. C. [1 ]
机构：
[1] Univ Lisbon, Fac Med, Inst Med Mol, P-1699 Lisbon, Portugal
[2] PeptiPharma, Rome, Italy
来源：
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 2013年 / 42卷
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
引用
收藏
页码：S165 / S165
页数：1
相关论文
共 50 条
  • [21] Molecular Dynamics Studies of the Inhibitor C34 Binding to the Wild-Type and Mutant HIV-1 gp41: Inhibitory and Drug Resistant Mechanism
    Ma, Xueting
    Tan, Jianjun
    Su, Min
    Li, Chunhua
    Zhang, Xiaoyi
    Wang, Cunxin
    PLOS ONE, 2014, 9 (11):
  • [22] A Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase in Inhibition Potency
    Nomura, Wataru
    Hashimoto, Chie
    Ohya, Aki
    Miyauchi, Kosuke
    Urano, Emiko
    Tanaka, Tomohiro
    Narumi, Tetsuo
    Nakahara, Toru
    Komano, Jun A.
    Yamamoto, Naoki
    Tamamura, Hirokazu
    CHEMMEDCHEM, 2012, 7 (02) : 205 - 208
  • [23] A first-in-human study of the novel HIV-fusion inhibitor C34-PEG4-Chol
    Quinn, Killian
    Traboni, Cinzia
    Penchala, Sujan Dily
    Bouliotis, Georgios
    Doyle, Nicki
    Libri, Vincenzo
    Khoo, Saye
    Ashby, Deborah
    Weber, Jonathan
    Nicosia, Alfredo
    Cortese, Riccardo
    Pessi, Antonello
    Winston, Alan
    SCIENTIFIC REPORTS, 2017, 7
  • [24] A first-in-human study of the novel HIV-fusion inhibitor C34-PEG4-Chol
    Killian Quinn
    Cinzia Traboni
    Sujan Dily Penchala
    Georgios Bouliotis
    Nicki Doyle
    Vincenzo Libri
    Saye Khoo
    Deborah Ashby
    Jonathan Weber
    Alfredo Nicosia
    Riccardo Cortese
    Antonello Pessi
    Alan Winston
    Scientific Reports, 7
  • [25] Chemoenzymatic synthesis of HIV-1 gp41 glycopeptides:: Effects of glycosylation on the anti-HIV activity and α-helix bundle-forming ability of peptide C34
    Wang, LX
    Song, HJ
    Liu, SW
    Lu, H
    Jiang, SB
    Ni, JH
    Li, HG
    CHEMBIOCHEM, 2005, 6 (06) : 1068 - 1074
  • [26] A Compensatory Mutation Provides Resistance to Disparate HIV Fusion Inhibitor Peptides and Enhances Membrane Fusion
    Wood, Matthew P.
    Cole, Amy L.
    Ruchala, Piotr
    Waring, Alan J.
    Rohan, Lisa C.
    Marx, Preston
    Tarwater, Patrick M.
    Gupta, Phalguni
    Cole, Alexander M.
    PLOS ONE, 2013, 8 (02):
  • [27] A first-in-human study, in HIV-positive men, of the novel HIV-fusion inhibitor C34-PEG4-Chol
    Quinn, K.
    Bouliotis, G.
    Doyle, N.
    Winston, A.
    Ashby, D.
    Weber, J.
    Libri, V.
    Amara, A.
    Back, D.
    Penchala, S. D.
    Khoo, S.
    Nelson, M.
    Jones, R.
    Cortese, R.
    Pessi, A.
    HIV MEDICINE, 2016, 17 : 18 - 18
  • [28] Insertion and anchoring of HIV-1 fusion peptide into complex membrane mimicking the human T cell
    Zhao, Mingfei
    Meale, Chris
    Sahni, Harshita
    Yadav, Anju
    Reddy, Tyler J. E.
    Lopez, Cesar A.
    Gnanakaran, Sandrasegaram
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 329A - 329A
  • [29] Peptide Assembly on the Membrane Determines the HIV-1 Inhibitory Activity of Dual-Targeting Fusion Inhibitor Peptides
    Gomara, Maria J.
    Perez, Yolanda
    Martinez, Javier P.
    Barnadas-Rodriguez, Ramon
    Schultz, Anke
    von Briesen, Hagen
    Peralvarez-Marin, Alex
    Meyerhans, Andreas
    Haro, Isabel
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [30] Peptide Assembly on the Membrane Determines the HIV-1 Inhibitory Activity of Dual-Targeting Fusion Inhibitor Peptides
    Maria J. Gomara
    Yolanda Perez
    Javier P. Martinez
    Ramon Barnadas-Rodriguez
    Anke Schultz
    Hagen von Briesen
    Alex Peralvarez-Marin
    Andreas Meyerhans
    Isabel Haro
    Scientific Reports, 9
12345