A Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase in Inhibition Potency

被引：37
|
作者：
Nomura, Wataru [1 ]
Hashimoto, Chie [1 ]
Ohya, Aki [1 ]
Miyauchi, Kosuke [2 ]
Urano, Emiko [2 ]
Tanaka, Tomohiro [1 ]
Narumi, Tetsuo [1 ]
Nakahara, Toru [1 ]
Komano, Jun A. [2 ]
Yamamoto, Naoki [3 ]
Tamamura, Hirokazu [1 ]
机构：
[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan
[2] Natl Inst Infect Dis, AIDS Res Ctr, Shinjuku Ku, Tokyo 1628640, Japan
[3] Natl Univ Singapore, Dept Microbiol, Yong Loo Lin Sch Med, Singapore 117597, Singapore
来源：
CHEMMEDCHEM | 2012年 / 7卷 / 02期
关键词：
antiviral agents; C34; trimers; fusion inhibitors; gp41; HIV-1; IMMUNODEFICIENCY-VIRUS TYPE-1; NATIVE CHEMICAL LIGATION; VIRAL MEMBRANE-FUSION; ENVELOPE GLYCOPROTEINS; PEPTIDE INHIBITOR; CORE STRUCTURE; COILED-COIL; ENTRY; INFECTION; MECHANISMS;
D O I：
10.1002/cmdc.201100542
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：205 / 208
页数：4
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