Pharmacology and genetics of autism: implications for diagnosis and treatment
被引:8
|
作者:
Brkanac, Zoran
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
Univ Washington, Seattle Childrens Hosp, Seattle, WA 98195 USAUniv Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
Brkanac, Zoran
[1
,2
]
Raskind, Wendy H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
Univ Washington, Seattle Childrens Hosp, Seattle, WA 98195 USA
Univ Washington, Div Med Genet, Dept Med, Seattle, WA 98195 USAUniv Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
Raskind, Wendy H.
[1
,2
,3
]
King, Bryan H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
Univ Washington, Seattle Childrens Hosp, Seattle, WA 98195 USAUniv Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
King, Bryan H.
[1
,2
]
机构:
[1] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
[2] Univ Washington, Seattle Childrens Hosp, Seattle, WA 98195 USA
[3] Univ Washington, Div Med Genet, Dept Med, Seattle, WA 98195 USA
autism;
disease-modifying treatments;
fragile X;
genetics;
molecular pathways;
Rett syndrome;
D O I:
10.2217/17410541.5.6.599
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Autism has the highest estimated heritability (>90%) among behaviorally defined neuropsychiatric disorders. Rapidly advancing genomic technologies and large international collaborations have increased our understanding of the molecular genetic causes of autism. Pharmacogenomic approaches are currently being applied in two single-gene disorders, fragile X syndrome and Rett syndrome, which capture many aspects of the autistic phenotype. This review describes the current state of the genetics of autism and suggests how to extend pharmacological principles pioneered in fragile X and Rett to the broader group of patients with autism.