Pharmacology and genetics of autism: implications for diagnosis and treatment

被引：8
|
作者：
Brkanac, Zoran [1 ,2 ]
Raskind, Wendy H. [1 ,2 ,3 ]
King, Bryan H. [1 ,2 ]
机构：
[1] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
[2] Univ Washington, Seattle Childrens Hosp, Seattle, WA 98195 USA
[3] Univ Washington, Div Med Genet, Dept Med, Seattle, WA 98195 USA
来源：
PERSONALIZED MEDICINE | 2008年 / 5卷 / 06期
基金：
美国国家卫生研究院;
关键词：
autism; disease-modifying treatments; fragile X; genetics; molecular pathways; Rett syndrome;
D O I：
10.2217/17410541.5.6.599
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Autism has the highest estimated heritability (>90%) among behaviorally defined neuropsychiatric disorders. Rapidly advancing genomic technologies and large international collaborations have increased our understanding of the molecular genetic causes of autism. Pharmacogenomic approaches are currently being applied in two single-gene disorders, fragile X syndrome and Rett syndrome, which capture many aspects of the autistic phenotype. This review describes the current state of the genetics of autism and suggests how to extend pharmacological principles pioneered in fragile X and Rett to the broader group of patients with autism.
引用
收藏
页码：599 / 607
页数：9
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