Thioredoxin-1 expression regulated by morphine in SH-SY5Y cells

被引：13
|
作者：
Luo, Fu-Cheng [1 ]
Feng, Yue-Mei [1 ]
Zhao, Lu [1 ]
Li, Kui [1 ]
Wang, Sheng-Dong [1 ]
Song, Jun-Ying [1 ]
Bai, Jie [1 ]
机构：
[1] Kunming Univ Sci & Technol, Fac Med, Kunming 650500, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2012年 / 523卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Morphine; Thioredoxin-1; Opioid receptor; MU-OPIOID RECEPTOR; NF-KAPPA-B; PLACE PREFERENCE; WITHDRAWAL SYNDROME; OXIDATIVE STRESS; REDOX REGULATION; ERK PATHWAY; MICE; ACTIVATION; DEPENDENCE;
D O I：
10.1016/j.neulet.2012.06.039
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Attempts are being made to identify genes targeted by morphine. It is beneficial for developing new treatments that alleviate side-effects of morphine. Thioredoxin-1 is a small ubiquitous protein that has various biological activities, such as the control of redox balance, the inhibition of apoptosis and the modulation of inflammation. In this study, we found that thioredoxin-1 was induced by morphine in SH-SY5Y cells. Furthermore, opioid receptor. PI3K and ERK pathways were involved in morphine-induced increase of thioredoxin-1 expression. These results suggest that thioredoxin-1 maybe play a role in the actions of morphine. More detailed analysis could clarify cellular and molecular mechanisms involved in the actions of morphine. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：50 / 55
页数：6
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