Thioredoxin-1 expression regulated by morphine in SH-SY5Y cells

被引：13
|
作者：
Luo, Fu-Cheng [1 ]
Feng, Yue-Mei [1 ]
Zhao, Lu [1 ]
Li, Kui [1 ]
Wang, Sheng-Dong [1 ]
Song, Jun-Ying [1 ]
Bai, Jie [1 ]
机构：
[1] Kunming Univ Sci & Technol, Fac Med, Kunming 650500, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2012年 / 523卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Morphine; Thioredoxin-1; Opioid receptor; MU-OPIOID RECEPTOR; NF-KAPPA-B; PLACE PREFERENCE; WITHDRAWAL SYNDROME; OXIDATIVE STRESS; REDOX REGULATION; ERK PATHWAY; MICE; ACTIVATION; DEPENDENCE;
D O I：
10.1016/j.neulet.2012.06.039
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Attempts are being made to identify genes targeted by morphine. It is beneficial for developing new treatments that alleviate side-effects of morphine. Thioredoxin-1 is a small ubiquitous protein that has various biological activities, such as the control of redox balance, the inhibition of apoptosis and the modulation of inflammation. In this study, we found that thioredoxin-1 was induced by morphine in SH-SY5Y cells. Furthermore, opioid receptor. PI3K and ERK pathways were involved in morphine-induced increase of thioredoxin-1 expression. These results suggest that thioredoxin-1 maybe play a role in the actions of morphine. More detailed analysis could clarify cellular and molecular mechanisms involved in the actions of morphine. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：50 / 55
页数：6
相关论文
共 50 条
  • [31] Paraoxon-Induced Protein Expression Changes to SH-SY5Y Cells
    Prins, John M.
    George, Kathleen M.
    Thompson, Charles M.
    CHEMICAL RESEARCH IN TOXICOLOGY, 2010, 23 (11) : 1656 - 1662
  • [32] Valproic acid alters differential protein expression in SH-SY5Y cells
    Dong, Zhong
    Wang, Ying
    Chang, Ming
    Li, Guoyi
    Hu, Linsen
    NEURAL REGENERATION RESEARCH, 2011, 6 (27) : 2134 - 2139
  • [33] Morphine protects SH-SY5Y human neuroblastoma cells against Dickkopf1-induced apoptosis
    Wang, Kun-Peng
    Bai, Yu
    Wang, Jian
    Zhang, Jin-Zhen
    MOLECULAR MEDICINE REPORTS, 2015, 11 (02) : 1174 - 1180
  • [34] The roles of thioredoxin in protection against oxidative stress-induced apoptosis in SH-SY5Y cells
    Andoh, T
    Chock, PB
    Chiueh, CC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (12) : 9655 - 9660
  • [35] Protection against oxidant-induced apoptosis by mitochondrial thioredoxin in SH-SY5Y neuroblastoma cells
    Chen, Yan
    Yu, Min
    Jones, Dean P.
    Greenamyre, J. Timothy
    Cai, Jiyang
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2006, 216 (02) : 256 - 262
  • [36] Aβ induces endothelin-1 production by SH-SY5Y neuroblastoma cells
    Palmer, J. C.
    Kehoe, P. G.
    Love, S.
    BRAIN PATHOLOGY, 2010, 20 : 18 - 18
  • [37] Human TAO kinase 1 induces apoptosis in SH-SY5Y cells
    Wu, Ming-Fang
    Wang, Shyang-Guang
    CELL BIOLOGY INTERNATIONAL, 2008, 32 (01) : 151 - 156
  • [38] In vitro cytotoxicity of montelukast in HAPI and SH-SY5Y cells
    Tseng, Yu-Ting
    Cox, Tynan M.
    Grant, Gary D.
    Arora, Devinder
    Hall, Susan
    McFarland, Amelia J.
    Ekberg, Jenny
    Rudrawar, Santosh
    Anoopkumar-Dukie, Shailendra
    CHEMICO-BIOLOGICAL INTERACTIONS, 2020, 326
  • [39] The influence of α-synuclein on SH-SY5Y cells treated with rotenone
    Liu, Y.
    Yang, H.
    JOURNAL OF NEUROCHEMISTRY, 2007, 102 : 55 - 55
  • [40] OPIOID AGONISTS BINDING AND RESPONSES IN SH-SY5Y CELLS
    COSTA, EM
    HOFFMAN, BB
    LOEW, GH
    LIFE SCIENCES, 1992, 50 (01) : 73 - 81
12345