2,2-Bis(trifluoromethyl)-2,3-dihydro-1H-1,5-benzodiazepines

被引：1
|
作者：
Petko, K. I. [1 ]
Vorobey, V. M. [1 ]
Gutov, A. V. [1 ]
Chernega, A. N. [1 ]
机构：
[1] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02660 Kiev, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 08期
关键词：
1,5-benzodiazepines; hexafluoroacetone N-phenylimines; X-ray structural analysis;
D O I：
10.1007/s10593-013-1360-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for the cyclization of hexafluoroacetone N-phenylimine derivatives with the formation of benzodiazepine analogs containing trifluromethyl groups has been elaborated. The obtained compounds were characterized by the NMR and mass spectral analysis and by the data from X-ray structural analysis.
引用
收藏
页码：1172 / 1179
页数：8
相关论文
共 50 条
  • [21] Microwave assisted synthesis of 2,4-diaryl-2,3-dihydro-1H-1,5-benzodiazepines on solventless inorganic solid support and their antibacterial activities
    Dulawat, Shiv S.
    Roy, Ravindra S.
    Chundawat, Jagveer S.
    Chundawat, Sumer S.
    AFINIDAD, 2008, 65 (537) : 404 - 409
  • [22] Clozapine derived 2,3-dihydro-1H-1,4-and 1,5-benzodiazepines with D4 receptor selectivity:: synthesis and biological testing
    Hussenether, T
    Hübner, H
    Gmeiner, P
    Troschütz, R
    BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (10) : 2625 - 2637
  • [23] Lewis Acid-Mediated Ring Contraction of 2,4-Diaryl-2,3-dihydro-1H-1,5-benzodiazepines: Access to 2-Aryl-1-styrylbenzimidazoles
    Zhang, Mengyao
    Wu, Qiuyue
    Xu, Jiaxi
    HELVETICA CHIMICA ACTA, 2023, 106 (04)
  • [24] 2,2-Bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizin-1-one
    Ali, Yousuf
    Peng, Yu
    Hua, Erbing
    Afza, Nighat
    Khan, Rashid Ali
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1579 - U643
  • [25] INTERACTION OF 2,3-DIHYDRO-1H-1,5-BENZODIAZEPINONE-2 WITH EPICHLORHYDRINE
    Gaponov, Oleksandr O.
    Tarabara, Igor M.
    BULLETIN OF DNIPROPETROVSK UNIVERSITY-SERIES CHEMISTRY, 2014, 22 (01): : 67 - 70
  • [26] AROMATIC DERIVATIVES 2,3-DIHYDRO-1H-1,5-BENZODIAZEPINE
    ORLOV, VD
    DESENKO, SM
    KIROGA, K
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1987, (03): : 370 - 375
  • [27] Investigation of Various Organocatalysts for Improved and Efficient One Pot Synthesis of 2,3-Dihydro-1H-1,5-benzodiazepines Under Solvent-Free Condition
    Zhao, Yuhao
    Sharma, Shikha
    Huang, Minghua
    Sandhar, Akshdeep
    Singh, Rajesh K.
    Ma, Yanxu
    ASIAN JOURNAL OF CHEMISTRY, 2014, 26 (16) : 5116 - 5120
  • [28] 2,4-Bis(4-fluorophenyl)-2,3-dihydro-1H-1,5-benzodiazepine
    Baktir, Zeliha
    Akkurt, Mehmet
    Samshuddin, S.
    Narayana, B.
    Yathirajan, H. S.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1262 - U1669
  • [29] SYNTHESIS AND SPECTRAL STUDIES OF SOME 2,3-DIHYDRO-2,4-DIPHENYL-1H-1,5-BENZODIAZEPINES
    SRIVASTAVA, YK
    VERMA, BL
    NATIONAL ACADEMY SCIENCE LETTERS-INDIA, 1990, 13 (02): : 55 - 57
  • [30] SYNTHESIS AND PHARMACOLOGICAL STUDY OF 2,3-DIHYDRO-1H-1,5-BENZODIAZEPINONES-2
    STOLYARCHUK, AA
    FURMAN, YN
    PIKALOV, VL
    SOLOMKO, ZF
    TKACHENKO, VS
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1975, 9 (08): : 19 - 21
12345