A 22 kDa polyanion inhibits carnitine-dependent fatty acid oxidation in rat liver mitochondria

被引：23
|
作者：
Turkaly, P
Kerner, J
Hoppel, C
机构：
[1] Case Western Reserve Univ, Dept Vet Affairs Med Ctr, Dept Nutr, Med Res Serv 151W, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Vet Affairs Med Ctr, Dept Med, Med Res Serv 151W, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Dept Vet Affairs Med Ctr, Dept Pharmacol, Med Res Serv 151W, Cleveland, OH 44106 USA
来源：
FEBS LETTERS | 1999年 / 460卷 / 02期
关键词：
mitochondrion; carniline; fatty acid oxidation; porin; polyanion; carnitine palmitoyltransferase;
D O I：
10.1016/S0014-5793(99)01354-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The transport of activated fatty acids across the mitochondrial outer membrane has not been fully addressed. A polyanion (M-n = 22 kDa) inhibited the ADP-stimulated carnitine-dependent oxidation of both palmitoyl-CoA and palmitate plus CoA as well as mitochondrial hexokinase binding. In contrast, the oxidation of palmitoylcarnitine plus malate, as well as glutamate oxidation, was essentially unaffected. Mitochondrial carnitine palmitoyltransferase-1 was not inhibited bg the polyanion. The data suggest an additional component in carnitine-dependent mitochondrial fatty acid oxidation, possibly porin. (C) 1999 Federation of European Biochemical Societies.
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页码：241 / 245
页数：5
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