High-capacity adenoviral vectors for gene transfer and somatic gene therapy

被引：137
|
作者：
Kochanek, S [1 ]
机构：
[1] Univ Cologne, Ctr Mol Med, D-50931 Cologne, Germany
来源：
HUMAN GENE THERAPY | 1999年 / 10卷 / 15期
关键词：
D O I：
10.1089/10430349950016807
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The availability of efficient and nontoxic gene delivery technologies is fundamental to the translation of therapeutic concepts into clinical practice by gene transfer. High-capacity adenoviral (HC-Ad) vectors are characterized by the ability to transduce cells in vitro and in vivo with more than 30 kb of nonviral DNA, This quality allows simultaneous gene transfer of several expression cassettes, large promoters, and some genes in their natural genomic context. Because all viral coding sequences are removed from these vectors, safety is considerably improved compared with previous-generation adenoviral vectors.
引用
收藏
页码：2451 / 2459
页数：9
相关论文
共 50 条
  • [41] Delivery of adenoviral vectors to the prostate for gene therapy
    Lu, Y
    Carraher, J
    Zhang, Y
    Armstrong, J
    Lerner, J
    Rogers, WP
    Steiner, MS
    CANCER GENE THERAPY, 1999, 6 (01) : 64 - 72
  • [42] Gene therapy progress and prospects: adenoviral vectors
    J A St George
    Gene Therapy, 2003, 10 : 1135 - 1141
  • [43] Adenoviral vectors - A promising tool for gene therapy
    Ghosh, SS
    Gopinath, P
    Ramesh, A
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2006, 133 (01) : 9 - 29
  • [44] Adenoviral Vectors for Gene Therapy of Hereditary Diseases
    Muravyeva, Anna
    Smirnikhina, Svetlana
    BIOLOGY-BASEL, 2024, 13 (12):
  • [45] Purification of adenoviral gene therapy vectors.
    Ulrich, DL
    Wilhelm, ES
    Iyer, PR
    Vacante, DA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U252 - U252
  • [46] Chromatographic purification of adenoviral vectors for gene therapy
    Eglon, Marc
    Duffy, Aoife
    O'Brien, Timothy
    Strappe, Padraig
    HUMAN GENE THERAPY, 2008, 19 (10) : 1200 - 1200
  • [47] Improvement of adenoviral vectors for human gene therapy
    Vigne, E
    Dedieu, JF
    Orsini, C
    Latta, M
    Klonjkowski, B
    Prost, E
    Lakich, MM
    Kremer, EJ
    Denefle, P
    Perricaudet, M
    Yeh, P
    GENETIC APPROACHES TO NONCOMMUNICABLE DISEASES, 1996, : 113 - 131
  • [48] Advances in adenoviral vectors for cancer gene therapy
    Bilbao, G
    GomezNavarro, J
    Contreras, JL
    Curiel, DT
    EXPERT OPINION ON THERAPEUTIC PATENTS, 1997, 7 (12) : 1427 - 1446
  • [49] Delivery of adenoviral vectors to the prostate for gene therapy
    Yi Lu
    John Carraher
    Yu Zhang
    Jianling Armstrong
    Jody Lerner
    William P Rogers
    Mitchell S Steiner
    Cancer Gene Therapy, 1999, 6 : 64 - 72
  • [50] An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches
    Vanderkwaak, TJ
    Wang, MH
    Gómez-Navarro, J
    Rancourt, C
    Dmitriev, I
    Krasnykh, V
    Barnes, M
    Siegal, GP
    Alvarez, R
    Curiel, DT
    GYNECOLOGIC ONCOLOGY, 1999, 74 (02) : 227 - 234
12345