High-capacity adenoviral vectors for gene transfer and somatic gene therapy

被引：137
|
作者：
Kochanek, S [1 ]
机构：
[1] Univ Cologne, Ctr Mol Med, D-50931 Cologne, Germany
来源：
HUMAN GENE THERAPY | 1999年 / 10卷 / 15期
关键词：
D O I：
10.1089/10430349950016807
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The availability of efficient and nontoxic gene delivery technologies is fundamental to the translation of therapeutic concepts into clinical practice by gene transfer. High-capacity adenoviral (HC-Ad) vectors are characterized by the ability to transduce cells in vitro and in vivo with more than 30 kb of nonviral DNA, This quality allows simultaneous gene transfer of several expression cassettes, large promoters, and some genes in their natural genomic context. Because all viral coding sequences are removed from these vectors, safety is considerably improved compared with previous-generation adenoviral vectors.
引用
收藏
页码：2451 / 2459
页数：9
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