The Contribution of Key Enzyme-Substrate Interactions to the Cytochrome P450 Catalyzed Dehydrogenation of Tamoxifen Metabolites and the Role of P450 Conformational Dynamics during Tamoxifen Metabolism

被引：0
|
作者：
Shahrokh, Kiumars [1 ]
Yost, Garold S. [1 ]
Cheatham, Thomas E., III [2 ,3 ,4 ]
机构：
[1] Univ Utah, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 USA
[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84117 USA
[3] Univ Utah, Dept Pharmaceut, Salt Lake City, UT 84117 USA
[4] Univ Utah, Dept Pharmaceut Chem, Salt Lake City, UT 84117 USA
来源：
CHEMICAL RESEARCH IN TOXICOLOGY | 2008年 / 21卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
22
引用
收藏
页码：2437 / 2437
页数：1
相关论文
共 50 条
  • [41] The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
    Goetz, Matthew P.
    Knox, Stacey K.
    Suman, Vera J.
    Rae, James M.
    Safgren, Stephanie L.
    Ames, Matthew M.
    Visscher, Daniel W.
    Reynolds, Carol
    Couch, Fergus J.
    Lingle, Wilma L.
    Weinshilboum, Richard M.
    Fritcher, Emily G. Barr
    Nibbe, Andrea M.
    Desta, Zeruesenay
    Nguyen, Anne
    Flockhart, David A.
    Perez, Edith A.
    Ingle, James N.
    BREAST CANCER RESEARCH AND TREATMENT, 2007, 101 (01) : 113 - 121
  • [42] The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
    Matthew P. Goetz
    Stacey K. Knox
    Vera J. Suman
    James M. Rae
    Stephanie L. Safgren
    Matthew M. Ames
    Daniel W. Visscher
    Carol Reynolds
    Fergus J. Couch
    Wilma L. Lingle
    Richard M. Weinshilboum
    Emily G. Barr Fritcher
    Andrea M. Nibbe
    Zeruesenay Desta
    Anne Nguyen
    David A. Flockhart
    Edith A. Perez
    James N. Ingle
    Breast Cancer Research and Treatment, 2007, 101 : 113 - 121
  • [43] Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium
    Hukkanen, J
    Mantyla, M
    Kangas, L
    Wirta, P
    Hakkola, J
    Paakki, P
    Evisalmi, S
    Pelkonen, O
    Raunio, H
    PHARMACOLOGY & TOXICOLOGY, 1998, 82 (02): : 93 - 97
  • [44] Role of cytochrome P450 activity in the fate of anticancer agents and in drug resistance - Focus on tamoxifen, paclitaxel and imatinib metabolism
    Rochat, B
    CLINICAL PHARMACOKINETICS, 2005, 44 (04) : 349 - 366
  • [45] Conformational dynamics in cytochrome P450-substrate interactions
    Li, H
    Poulos, TL
    BIOCHIMIE, 1996, 78 (8-9) : 695 - 699
  • [46] CYTOCHROME P450 - ROLE IN DRUG METABOLISM AND GENETIC POLYMORPHISM
    Nandagopal, Anitha
    Unnisa, Syeda Viquar
    Shireen, Bushra
    Tasleem, Sheema
    INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 5 (04): : 2979 - 2989
  • [47] Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs
    Quinones S, Luis
    Rosero P, Mario
    Roco A, Angela
    Moreno T, Ivan
    Sasso A, Jaime
    Varela F, Nelson
    Caceres L, Dante
    Saavedra S, Ivan
    REVISTA MEDICA DE CHILE, 2008, 136 (10) : 1327 - 1335
  • [48] The role of cytochrome P450 enzymes In metabolism of acrylamide in vitro
    Tomalik-Scharte, D.
    Rokitta, D.
    Fuhr, U.
    Kunz, D.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2011, 383 : 97 - 97
  • [49] Role of cytochrome P450 enzymes in fimasartan metabolism in vitro
    Choi, Young Jae
    Lee, Ji-Yoon
    Ryu, Chang Seon
    Ha Chi, Yong
    Paik, Soo Heui
    Kim, Sang Kyum
    FOOD AND CHEMICAL TOXICOLOGY, 2018, 115 : 375 - 384
  • [50] The role of intestinal Cytochrome P450 in vitamin D metabolism
    Uga, Minori
    Kaneko, Ichiro
    Sasaki, Sumire
    Koike, Megumi
    Tanifuji, Kazuya
    Kawahara, Kota
    Shiozaki, Yuji
    Jurutka, Peter W.
    Segawa, Hiroko
    ANNALS OF NUTRITION AND METABOLISM, 2023, 79 : 670 - 670
12345