The Contribution of Key Enzyme-Substrate Interactions to the Cytochrome P450 Catalyzed Dehydrogenation of Tamoxifen Metabolites and the Role of P450 Conformational Dynamics during Tamoxifen Metabolism

被引:0
|
作者
Shahrokh, Kiumars [1 ]
Yost, Garold S. [1 ]
Cheatham, Thomas E., III [2 ,3 ,4 ]
机构
[1] Univ Utah, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 USA
[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84117 USA
[3] Univ Utah, Dept Pharmaceut, Salt Lake City, UT 84117 USA
[4] Univ Utah, Dept Pharmaceut Chem, Salt Lake City, UT 84117 USA
关键词
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
22
引用
收藏
页码:2437 / 2437
页数:1
相关论文
共 50 条
  • [21] Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development
    Kandel, Sylvie E.
    Wienkers, Larry C.
    Lampe, Jed N.
    ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 49, 2014, 49 : 347 - 359
  • [22] Conformational selectivity in cytochrome P450 redox partner interactions
    Hollingsworth, Scott A.
    Batabyal, Dipanwita
    Nguyen, Brian D.
    Poulos, Thomas L.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (31) : 8723 - 8728
  • [23] Interactions Between Tamoxifen and Antidepressants via Cytochrome P450 2D6
    Desmarais, Julie Eve
    Looper, Karl J.
    JOURNAL OF CLINICAL PSYCHIATRY, 2009, 70 (12) : 1688 - 1697
  • [24] Role of cytochrome P450 in estradiol metabolism in vitro
    Cheng, ZN
    Shu, Y
    Liu, ZQ
    Wang, LS
    Ou-Yang, DS
    Zhou, HH
    ACTA PHARMACOLOGICA SINICA, 2001, 22 (02) : 148 - 154
  • [25] Role of Cytochrome P450 Activity in the Fate of Anticancer Agents and in Drug ResistanceFocus on Tamoxifen, Paclitaxel and Imatinib Metabolism
    Bertrand Rochat
    Clinical Pharmacokinetics, 2005, 44 : 349 - 366
  • [26] The role of cytochrome P450 in antiretroviral drug interactions
    Walubo, Andrew
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2007, 3 (04) : 583 - 598
  • [27] Substrate Driven Allostery in a Mitochondrial Cytochrome P450 Enzyme
    Kumar, Amit
    Fernando, D. Estrada
    BIOPHYSICAL JOURNAL, 2019, 116 (03) : 487A - 487A
  • [28] Cytochrome P450 enzymes and their role in drug interactions
    Papp-Jámbor, C
    Jaschinski, U
    Forst, H
    ANAESTHESIST, 2002, 51 (01): : 2 - 15
  • [29] Aromatase cytochrome P450 - the key enzyme of estrogen synthesis
    Kowalewska-Luczak, Inga
    Kmiec, Marek
    Terman, Arkadiusz
    MEDYCYNA WETERYNARYJNA, 2006, 62 (08) : 870 - 872
  • [30] Effect of Salts on the Conformational Dynamics of the Cytochrome P450 OleP
    De Sciscio, Maria Laura
    Nardi, Alessandro Nicola
    Parisi, Giacomo
    Bulfaro, Giovanni
    Costanzo, Antonella
    Gugole, Elena
    Exertier, Cecile
    Freda, Ida
    Savino, Carmelinda
    Vallone, Beatrice
    Montemiglio, Linda Celeste
    D'Abramo, Marco
    MOLECULES, 2023, 28 (02):