Palladium-Catalyzed Aerobic Oxidative Cyclization of N-Aryl lmines: lndole Synthesis from Anilines and Ketones

被引：299

作者：

Wei, Ye ^{[1
]}

Deb, Indubhusan ^{[1
]}

Yoshikai, Naohiko ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 22期

基金：

新加坡国家研究基金会;

关键词：

C-H BOND; AROMATIC IMINES; INDOLES; ACTIVATION; ALKYNES; DIOXYGEN; OXIDANT; HECK;

D O I：

10.1021/ja3030824

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C-H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups.

引用

页码：9098 / 9101

页数：4

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