Palladium-Catalyzed Aerobic Oxidative Cyclization of N-Aryl lmines: lndole Synthesis from Anilines and Ketones

被引：299
|
作者：
Wei, Ye [1 ]
Deb, Indubhusan [1 ]
Yoshikai, Naohiko [1 ]
机构：
[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 22期
基金：
新加坡国家研究基金会;
关键词：
C-H BOND; AROMATIC IMINES; INDOLES; ACTIVATION; ALKYNES; DIOXYGEN; OXIDANT; HECK;
D O I：
10.1021/ja3030824
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C-H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups.
引用
收藏
页码：9098 / 9101
页数：4
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