Effects of cisplatin and other Pt(II) complexes on spontaneous motility of isolated human oviduct

The toxicity of platinum(lI) ion could be significantly modified by coordination with some organic compounds. In our study, the cytotoxicity and the influence of platinum(II) complexes, such as cisplatin, cis[PtCl2(NH3)(2)], [PtCl2(SMC)] and [PtCl2(DMSO)(2)] (where SMC is S-methyl-L-Cysteine and DMSO is dimethyl sulphoxide) on spontaneous motility of isolated human fallopian tubes were investigated. Cisplatin showed potent pro-apoptotic effects on peripheral blood mononuclear cells (PBMC) However, peripheral blood mononuclear cells were substantially less sensitive to [PtCl2(SMC)] and [PtCl2(DMSO)], and these compounds showed no toxic effect on PBMC in all concentrations examined. Cisplatin showed concentration-dependent inhibition of spontaneous contractions of the isolated ampulla. (EC50 = 1.14 +/- 0.03 x 10(-6) M/l, r = 0.714, p < 0.05) while [PtCl2(SMC)] and [PtCl2(DMSO)(2)] did not affect spontaneous contractions of isolated fallopian tube ampulla. (C) 2008 Elsevier Ltd. All rights reserved.