Effects of cisplatin and other Pt(II) complexes on spontaneous motility of isolated human oviduct

被引：6
|
作者：
Bugarcic, Zivadin D. [1 ]
Petrovic, Biljana [1 ]
Bugarcic, Zorica M. [1 ]
Jankovic, Slobodan M. [2 ]
Jankovic, Snezana V. [2 ]
Lukic, Goran [3 ]
Novakovic, Milan [2 ]
Kostovic, Vladimir [2 ]
Popovic, Suzana [2 ]
Djurdjevic, Predrag [2 ]
Baskic, Dejan [2 ]
Arsenijevic, Nebojsa [2 ]
机构：
[1] Univ Kragujevac, Fac Sci, Dept Chem, Kragujevac 34000, Serbia
[2] Univ Kragujevac, Dept Pharmacol & Toxicol, Fac Med, Kragujevac 34000, Serbia
[3] Univ Kragujevac, Clin Gynecol & Obstet, Fac Med, Kragujevac 34000, Serbia
来源：
TOXICOLOGY IN VITRO | 2008年 / 22卷 / 08期
关键词：
Platinum(II); Cytotoxicity; Human fallopian tubes;
D O I：
10.1016/j.tiv.2008.09.011
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The toxicity of platinum(lI) ion could be significantly modified by coordination with some organic compounds. In our study, the cytotoxicity and the influence of platinum(II) complexes, such as cisplatin, cis[PtCl2(NH3)(2)], [PtCl2(SMC)] and [PtCl2(DMSO)(2)] (where SMC is S-methyl-L-Cysteine and DMSO is dimethyl sulphoxide) on spontaneous motility of isolated human fallopian tubes were investigated. Cisplatin showed potent pro-apoptotic effects on peripheral blood mononuclear cells (PBMC) However, peripheral blood mononuclear cells were substantially less sensitive to [PtCl2(SMC)] and [PtCl2(DMSO)], and these compounds showed no toxic effect on PBMC in all concentrations examined. Cisplatin showed concentration-dependent inhibition of spontaneous contractions of the isolated ampulla. (EC50 = 1.14 +/- 0.03 x 10(-6) M/l, r = 0.714, p < 0.05) while [PtCl2(SMC)] and [PtCl2(DMSO)(2)] did not affect spontaneous contractions of isolated fallopian tube ampulla. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1878 / 1882
页数：5
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