Relationship of c-erbB-2 expression to clinicopathological features and prognosis in gastric cancer

被引：0
|
作者：
Karayiannakis, AJ [1 ]
Syrigos, KN [1 ]
Chatzigianni, E [1 ]
Valinos, P [1 ]
Bousiakos, P [1 ]
Balas, G [1 ]
Lakiotis, G [1 ]
Simatos, G [1 ]
机构：
[1] IKA Hosp 1, Dept Surg 1, Athens, Greece
来源：
3RD INTERNATIONAL GASTRIC CANCER CONGRESS | 1999年
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this study, the expression of c-erbB-2 was investigated immunohistochemically in 61 formalin-fixed, paraffin-embedded specimens of gastric carcinoma. Membranous c-erbB-2 immunoreactivity was observed in 36% of tumours. Intestinal type tumours had a significantly higher incidence of c-erbB-2 expression than did diffuse type tumours. c-erbB-2 expression correlated with serosal invasion, lymph node metastasis and advanced tumour stage compared with c-erbB-2 negative tumours. Survival rates of patients with c-erbB-2 positive carcinomas were significantly lower than those with c-erbB-2 negative carcinomas. These findings suggest that erbB-2 expression is associated with an aggressive phenotype and poor prognosis in gastric cancer.
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页码：269 / 272
页数：4
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