Relationship of c-erbB-2 expression to clinicopathological features and prognosis in gastric cancer

被引：0

作者：

Karayiannakis, AJ ^{[1
]}

Syrigos, KN ^{[1
]}

Chatzigianni, E ^{[1
]}

Valinos, P ^{[1
]}

Bousiakos, P ^{[1
]}

Balas, G ^{[1
]}

Lakiotis, G ^{[1
]}

Simatos, G ^{[1
]}

机构：

[1] IKA Hosp 1, Dept Surg 1, Athens, Greece

来源：

3RD INTERNATIONAL GASTRIC CANCER CONGRESS | 1999年

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, the expression of c-erbB-2 was investigated immunohistochemically in 61 formalin-fixed, paraffin-embedded specimens of gastric carcinoma. Membranous c-erbB-2 immunoreactivity was observed in 36% of tumours. Intestinal type tumours had a significantly higher incidence of c-erbB-2 expression than did diffuse type tumours. c-erbB-2 expression correlated with serosal invasion, lymph node metastasis and advanced tumour stage compared with c-erbB-2 negative tumours. Survival rates of patients with c-erbB-2 positive carcinomas were significantly lower than those with c-erbB-2 negative carcinomas. These findings suggest that erbB-2 expression is associated with an aggressive phenotype and poor prognosis in gastric cancer.

引用

页码：269 / 272

页数：4

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