Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer

被引：28
|
作者：
Sihto, Harri [1 ,2 ]
Joensuu, Heikki [1 ,2 ,3 ]
机构：
[1] Univ Helsinki, Mol Oncol Lab, Helsinki, Finland
[2] Univ Helsinki, Mol Canc Biol Program, Helsinki, Finland
[3] Univ Helsinki, Cent Hosp, Dept Oncol, Helsinki, Finland
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 08期
关键词：
cytotoxic T cells; Merkel cell carcinoma; Merkel cell polyomavirus; survival; tumor-infiltrating lymphocytes; T-ANTIGEN; POLYOMAVIRUS; INFECTION;
D O I：
10.4161/onci.21120
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
An intense immune infiltrate, enriched in T cells, is associated with the presence of Merkel cell polyomavirus (MCPyV) DNA in Merkel cell carcinoma (MCC), a rare skin cancer. High tumor-infiltrating T-cell counts are associated with favorable survival regardless of the tumor MCPyV status. Hence, boosting host immune functions might constitute a new approach for the treatment of MCC.
引用
收藏
页码：1420 / 1421
页数：2
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