Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer

被引：28

作者：

Sihto, Harri ^{[1
,2
]}

Joensuu, Heikki ^{[1
,2
,3
]}

机构：

[1] Univ Helsinki, Mol Oncol Lab, Helsinki, Finland

[2] Univ Helsinki, Mol Canc Biol Program, Helsinki, Finland

[3] Univ Helsinki, Cent Hosp, Dept Oncol, Helsinki, Finland

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 08期

关键词：

cytotoxic T cells; Merkel cell carcinoma; Merkel cell polyomavirus; survival; tumor-infiltrating lymphocytes; T-ANTIGEN; POLYOMAVIRUS; INFECTION;

D O I：

10.4161/onci.21120

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An intense immune infiltrate, enriched in T cells, is associated with the presence of Merkel cell polyomavirus (MCPyV) DNA in Merkel cell carcinoma (MCC), a rare skin cancer. High tumor-infiltrating T-cell counts are associated with favorable survival regardless of the tumor MCPyV status. Hence, boosting host immune functions might constitute a new approach for the treatment of MCC.

引用

页码：1420 / 1421

页数：2

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