A review on natural products with cage-like structure

被引：17
|
作者：
Li, Yutong [1 ]
Zhang, Linlin [1 ]
Wang, Wang [1 ]
Liu, Yang [1 ]
Sun, Dejuan [1 ]
Li, Hua [1 ,2 ]
Chen, Lixia [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Wuya Coll Innovat, Shenyang 110016, Peoples R China
[2] Fujian Univ Tradit Chinese Med, Coll Pharm, Fuzhou 350122, Peoples R China
来源：
BIOORGANIC CHEMISTRY | 2022年 / 128卷
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Cage compound; Natural product; Structure; Biological activity; Biosynthesis; POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOLS; ENMEIN-TYPE DITERPENOIDS; POLYISOPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES; MONOTERPENE GLYCOSIDES; PAEONIA-LACTIFLORA; UNPRECEDENTED QUASSINOIDS; BIOLOGICAL-ACTIVITIES; GARCINIA-MULTIFLORA; ADAMANTYL SKELETON; VAR; FRANCHETII;
D O I：
10.1016/j.bioorg.2022.106106
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Natural products with diverse structures and significant biological activities are essential sources of drug lead compounds, and play an important role in the research and development of innovative drugs. Cage-like com-pounds have various structures and are widely distributed in nature, especially caged xanthones isolated from Garcinia genus, paeoniflorin and its derivatives isolated from Paeonia lactiflora Pall, tetrodotoxin (TTX) and its derivatives, and so on. In recent years, the development and utilization of cage-like compounds have been a research hotspot in chemistry, biology and other fields due to their special structures and remarkable biological activities. In this review, we mainly summarized the cage-like compounds with various structures found and isolated from natural drugs since 1956, summarized its broad biological activities, and introduced the progress in the biosynthesis of some compounds, so as to provide a reference for the discovery of more novel compounds, and the development and application of innovative drugs.
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页数：19
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