A review on natural products with cage-like structure

被引：17
|
作者：
Li, Yutong [1 ]
Zhang, Linlin [1 ]
Wang, Wang [1 ]
Liu, Yang [1 ]
Sun, Dejuan [1 ]
Li, Hua [1 ,2 ]
Chen, Lixia [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Wuya Coll Innovat, Shenyang 110016, Peoples R China
[2] Fujian Univ Tradit Chinese Med, Coll Pharm, Fuzhou 350122, Peoples R China
来源：
BIOORGANIC CHEMISTRY | 2022年 / 128卷
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Cage compound; Natural product; Structure; Biological activity; Biosynthesis; POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOLS; ENMEIN-TYPE DITERPENOIDS; POLYISOPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES; MONOTERPENE GLYCOSIDES; PAEONIA-LACTIFLORA; UNPRECEDENTED QUASSINOIDS; BIOLOGICAL-ACTIVITIES; GARCINIA-MULTIFLORA; ADAMANTYL SKELETON; VAR; FRANCHETII;
D O I：
10.1016/j.bioorg.2022.106106
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Natural products with diverse structures and significant biological activities are essential sources of drug lead compounds, and play an important role in the research and development of innovative drugs. Cage-like com-pounds have various structures and are widely distributed in nature, especially caged xanthones isolated from Garcinia genus, paeoniflorin and its derivatives isolated from Paeonia lactiflora Pall, tetrodotoxin (TTX) and its derivatives, and so on. In recent years, the development and utilization of cage-like compounds have been a research hotspot in chemistry, biology and other fields due to their special structures and remarkable biological activities. In this review, we mainly summarized the cage-like compounds with various structures found and isolated from natural drugs since 1956, summarized its broad biological activities, and introduced the progress in the biosynthesis of some compounds, so as to provide a reference for the discovery of more novel compounds, and the development and application of innovative drugs.
引用
收藏
页数：19
相关论文
共 50 条
  • [21] Synthesis of cage-like octa(trimethylsiloxy)silsesquioxane
    HU Chunye
    Chinese Science Bulletin, 1999, (22) : 2044 - 2047
  • [22] A new approach to the synthesis of cage-like metallasiloxanes
    Molodtsova, YA
    Pozdniakova, YA
    Lyssenko, KA
    Blagodatskikh, IV
    Katsoulis, DE
    Shchegolikhina, OI
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1998, 571 (01) : 31 - 36
  • [23] ATOMIC IMAGING OF CAGE-LIKE STRUCTURES OF SILICON
    NISTOR, L
    VANTENDELOO, G
    AMELINCKX, S
    CROS, C
    PHYSICA STATUS SOLIDI A-APPLIED RESEARCH, 1994, 146 (01): : 119 - 132
  • [24] "Cage-Like" Phosphines: Design and Catalytic Properties
    Zablocka, Maria
    Hameau, Aurelien
    Caminade, Anne-Marie
    Majoral, Jean-Pierre
    ADVANCED SYNTHESIS & CATALYSIS, 2010, 352 (14-15) : 2341 - 2358
  • [25] Incorporation of niobium into cage-like silica mesostructures
    Nowak, Izabela
    Jaroniec, Mietek
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 483 - 483
  • [26] Synthesis of cage-like octa(trimethylsiloxy) silsesquioxane
    Hu, CY
    Qin, Y
    Yuan, CY
    CHINESE SCIENCE BULLETIN, 1999, 44 (22): : 2044 - 2047
  • [27] Cage-like structure and charge hollow in the immiscible Cu-Ta system
    Kong, Yi
    Du, Yong
    Li, Junqin
    SOLID STATE COMMUNICATIONS, 2009, 149 (43-44) : 1974 - 1977
  • [28] SYNTHESIS AND STRUCTURE OF A CAGE-LIKE SILIC ACID ESTER WITH FUNCTIONAL =SIH GROUPS
    HOEBBEL, D
    PITSCH, I
    GRIMMER, AR
    JANCKE, H
    HILLER, W
    HARRIS, RK
    ZEITSCHRIFT FUR CHEMIE, 1989, 29 (07): : 260 - 261
  • [29] ANALGESIC ACTIVITY OF CAGE-LIKE AMINES DERIVATIVES
    Zlenko, H. T.
    Zarovnaya, I. S.
    Palchikov, V. A.
    EUROPEAN PSYCHIATRY, 2013, 28
  • [30] Insight into a series of cage-like nitrogen oxides
    Tan, Bisheng
    Huang, Ming
    Long, Xinping
    Li, Jinshan
    Yuan, Xiaodong
    Xu, Ruijuan
    POLYHEDRON, 2014, 79 : 124 - 128
12345