An Efficient and Solvent-Free Synthesis of Mixed Ortho Esters

被引：3
|
作者：
Cosgrove, Kelly L. [1 ]
McGeary, Ross P. [1 ,2 ]
机构：
[1] Univ Queensland, Sch Mol & Microbial Sci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia
来源：
SYNLETT | 2008年 / 16期
关键词：
ortho esters; ketene dimethyl acetal; alcohols; cyanohydrins; 1,2-diols;
D O I：
10.1055/s-2008-1078215
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Primary, secondary and electron-deficient tertiary alcohols react rapidly with ketene dimethyl acetal to form mixed ortho esters, without catalysts and under solvent-free conditions. 1,2-Diols yield bis(mixed ortho esters), rather than cyclic ortho esters.
引用
收藏
页码：2425 / 2428
页数：4
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