An Efficient and Solvent-Free Synthesis of Mixed Ortho Esters

被引：3

作者：

Cosgrove, Kelly L. ^{[1
]}

McGeary, Ross P. ^{[1
,2
]}

机构：

[1] Univ Queensland, Sch Mol & Microbial Sci, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia

来源：

SYNLETT | 2008年 / 16期

关键词：

ortho esters; ketene dimethyl acetal; alcohols; cyanohydrins; 1,2-diols;

D O I：

10.1055/s-2008-1078215

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Primary, secondary and electron-deficient tertiary alcohols react rapidly with ketene dimethyl acetal to form mixed ortho esters, without catalysts and under solvent-free conditions. 1,2-Diols yield bis(mixed ortho esters), rather than cyclic ortho esters.

引用

页码：2425 / 2428

页数：4

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