One-Pot and Regiospecific Synthesis of 2,3-Disubstituted Indoles from 2-Bromoanilides via Consecutive Palladium-Catalyzed Sonogashira Coupling, Amidopalladation, and Reductive Elimination

被引：54
|
作者：
Lu, Bruce Z. [1 ]
Wei, Han-Xun [1 ]
Zhang, Yongda [1 ]
Zhao, Wenyi [1 ]
Dufour, Marine [1 ]
Li, Guisheng [1 ]
Farina, Vittorio [1 ]
Senanayake, Chris H. [1 ]
机构：
[1] Boehringer Ingelheim Pharmaceut Inc, Chem Dev, Ridgefield, CT 06877 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 09期
关键词：
ARYL CHLORIDES; RING SYNTHESIS; HYDROAMINATION; METHODOLOGY; DERIVATIVES; BROMIDES; ALKENES; ALKYNES; ACID;
D O I：
10.1021/jo302679f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical one-pot and regiospecific three-component process for the synthesis of 2,3-disubstituted indoles from 2-bromoanilides was developed via consecutive palladium catalyzed Sonogashira coupling, amidopalladafion, and reductive elimination.
引用
收藏
页码：4558 / 4562
页数：5
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