One-Pot and Regiospecific Synthesis of 2,3-Disubstituted Indoles from 2-Bromoanilides via Consecutive Palladium-Catalyzed Sonogashira Coupling, Amidopalladation, and Reductive Elimination

被引：54

作者：

Lu, Bruce Z. ^{[1
]}

Wei, Han-Xun ^{[1
]}

Zhang, Yongda ^{[1
]}

Zhao, Wenyi ^{[1
]}

Dufour, Marine ^{[1
]}

Li, Guisheng ^{[1
]}

Farina, Vittorio ^{[1
]}

Senanayake, Chris H. ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Chem Dev, Ridgefield, CT 06877 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 09期

关键词：

ARYL CHLORIDES; RING SYNTHESIS; HYDROAMINATION; METHODOLOGY; DERIVATIVES; BROMIDES; ALKENES; ALKYNES; ACID;

D O I：

10.1021/jo302679f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical one-pot and regiospecific three-component process for the synthesis of 2,3-disubstituted indoles from 2-bromoanilides was developed via consecutive palladium catalyzed Sonogashira coupling, amidopalladafion, and reductive elimination.

引用

页码：4558 / 4562

页数：5

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