Synthesis of Heterobenzyl Sulfoxides Enabled by Palladium- Catalyzed Allylic Alkylation of Sulfenate Anions with Allenamides

被引：6
|
作者：
Wang, Lei [1 ]
Wu, Shuaijie [1 ]
Zhang, Shuting [1 ]
Hu, Qianqian [1 ]
Wang, Qiang [1 ]
Sun, Jing [1 ]
Han, Ying [1 ]
Yan, Chao-Guo [1 ]
机构：
[1] Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 21期
基金：
中国国家自然科学基金;
关键词：
ARYL BENZYL SULFOXIDES; ENANTIOSELECTIVE ARYLATION; ASYMMETRIC-SYNTHESIS; PUMMERER REACTION; GENERATION; INHIBITORS; DISCOVERY; OXIDATION; CASCADES; STRATEGY;
D O I：
10.1021/acs.joc.2c01998
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient palladium-catalyzed allenamide allylic alkylation of sulfenate anions under mild conditions is demonstrated. The present methodology provides a practical protocol to access various sulfoxide-containing heterocyclic compounds. The salient features of this transformation include a broad substrate scope, good functional group tolerance, easy to scale-up, and ready synthetic transformation.
引用
收藏
页码：14646 / 14656
页数：11
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