Synthesis of Heterobenzyl Sulfoxides Enabled by Palladium- Catalyzed Allylic Alkylation of Sulfenate Anions with Allenamides

被引：6

作者：

Wang, Lei ^{[1
]}

Wu, Shuaijie ^{[1
]}

Zhang, Shuting ^{[1
]}

Hu, Qianqian ^{[1
]}

Wang, Qiang ^{[1
]}

Sun, Jing ^{[1
]}

Han, Ying ^{[1
]}

Yan, Chao-Guo ^{[1
]}

机构：

[1] Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 21期

基金：

中国国家自然科学基金;

关键词：

ARYL BENZYL SULFOXIDES; ENANTIOSELECTIVE ARYLATION; ASYMMETRIC-SYNTHESIS; PUMMERER REACTION; GENERATION; INHIBITORS; DISCOVERY; OXIDATION; CASCADES; STRATEGY;

D O I：

10.1021/acs.joc.2c01998

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient palladium-catalyzed allenamide allylic alkylation of sulfenate anions under mild conditions is demonstrated. The present methodology provides a practical protocol to access various sulfoxide-containing heterocyclic compounds. The salient features of this transformation include a broad substrate scope, good functional group tolerance, easy to scale-up, and ready synthetic transformation.

引用

页码：14646 / 14656

页数：11

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