Synthesis of 3-azaharman and other new azacarbolines of the pyridazino[4,5-b]indole type

被引：9
|
作者：
El-Kashef, H
Farghaly, AAH
Floriani, S
Haider, N [1 ]
机构：
[1] Univ Vienna, Dept Pharmaceut Chem, Althanstr 14, A-1090 Vienna, Austria
[2] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt
来源：
ARKIVOC | 2003年
关键词：
pyridazino[4,5-b]indoles; azacarbolines; azaharman; antitumor agents;
D O I：
10.3998/ark.5550190.0004.e19
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Starting from the indole-fused pyridazinone 3, a series of new pyridazino[4,5-b]indoles, functionalized at positions 1, 2, or 5 was prepared, including the two tetracyclic compounds 12 and 13, which represent new ring systems. Reductive dehalogenation of the chloro compound 8 gave a 3-aza isoster of the natural product, harman.
引用
收藏
页码：198 / 209
页数：12
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