Synthesis of 3-azaharman and other new azacarbolines of the pyridazino[4,5-b]indole type

被引：9

作者：

El-Kashef, H

Farghaly, AAH

Floriani, S

Haider, N ^{[1
]}

机构：

[1] Univ Vienna, Dept Pharmaceut Chem, Althanstr 14, A-1090 Vienna, Austria

[2] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt

来源：

ARKIVOC | 2003年

关键词：

pyridazino[4,5-b]indoles; azacarbolines; azaharman; antitumor agents;

D O I：

10.3998/ark.5550190.0004.e19

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from the indole-fused pyridazinone 3, a series of new pyridazino[4,5-b]indoles, functionalized at positions 1, 2, or 5 was prepared, including the two tetracyclic compounds 12 and 13, which represent new ring systems. Reductive dehalogenation of the chloro compound 8 gave a 3-aza isoster of the natural product, harman.

引用

页码：198 / 209

页数：12

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