A Diverted Total Syntheses of Potent Cell Adhesion Inhibitor Peribysin E Analogues

被引：13
|
作者：
Handore, Kishor L. [1 ]
Reddy, D. Srinivasa [1 ]
机构：
[1] CSIR Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 08期
关键词：
DIELS-ALDER REACTIONS; NATURAL-PRODUCTS; GENERAL-APPROACH; EFFICIENT; EREMOPHILANES; CATALYSIS; REVISION; ROUTE;
D O I：
10.1021/ol400555m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Preliminary results from a program aimed at the creation of a focused library of analogues around the natural product peribysin E, a potent biologically active and structurally fascinating molecule, are reported. The total synthesis of (+/-)-peribysin E was accomplished using a short route. Eight new analogues of the natural compound have been accomplished by means of "diverted total synthesis" in less than 10 steps. The present effort highlights protecting-group-free total syntheses and the shortest route to access these functionally embellished hydrindanes.
引用
收藏
页码：1894 / 1897
页数：4
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