A Diverted Total Syntheses of Potent Cell Adhesion Inhibitor Peribysin E Analogues

被引：13

作者：

Handore, Kishor L. ^{[1
]}

Reddy, D. Srinivasa ^{[1
]}

机构：

[1] CSIR Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 08期

关键词：

DIELS-ALDER REACTIONS; NATURAL-PRODUCTS; GENERAL-APPROACH; EFFICIENT; EREMOPHILANES; CATALYSIS; REVISION; ROUTE;

D O I：

10.1021/ol400555m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Preliminary results from a program aimed at the creation of a focused library of analogues around the natural product peribysin E, a potent biologically active and structurally fascinating molecule, are reported. The total synthesis of (+/-)-peribysin E was accomplished using a short route. Eight new analogues of the natural compound have been accomplished by means of "diverted total synthesis" in less than 10 steps. The present effort highlights protecting-group-free total syntheses and the shortest route to access these functionally embellished hydrindanes.

引用

页码：1894 / 1897

页数：4

共 44 条

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