NMR studies of telomeric nucleoprotein complexes involving the Myb-like domain of the human telomeric protein TRF2

被引：3

作者：

Bilbille, Y ^{[1
]}

Paquet, F ^{[1
]}

Meudal, H ^{[1
]}

Giraud-Panis, MJ ^{[1
]}

Lancelot, G ^{[1
]}

机构：

[1] CNRS, UPR 4301, Ctr Biophys Mol, F-45071 Orleans 2, France

来源：

COMPTES RENDUS CHIMIE | 2006年 / 9卷 / 3-4期

关键词：

NMR structure; telomere; DNA; quadruplex; Myb-TRF2 DNA binding protein;

D O I：

10.1016/j.crci.2005.06.016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to study the binding of the Myb-like domain of the human telomeric protein TRF2 (Myb-TRF2) with different structural components of the t-loop model, we report NMR studies of the binding of Myb-TRF2 protein with two repeats human telomeric DNA under three conformations. Our results showed that Myb-TRF2 binds to the duplex and even to the quadruplex and the random coil G-rich strand. The solution structure of Myb-TRF2 reported here looks like Myb-TRF1 suggesting similar DNA binding mode. As a matter of fact, we have shown that its binding to the human telomeric duplex presents great similarities with this of Myb-TRF1.

引用

页码：452 / 458

页数：7

共 50 条

[41] Telomere attrition, telomeric protein TRF1 and TRF2 expression and DNA damage response activation during bronchial and bronchiolo-alveolar carcinogenesis
Lantuejoul, Sylvie
Raynaud, Christophe
Gazzeri, Sylvie
Salameire, Dimitri
Moro-Sibilot, Denis
Soria, Jean-Charles
Brambilla, Elisabeth
JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (09) : S877 - S877
[42] Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells
Stout, Gerdine J.
Blasco, Maria A.
DISEASE MODELS & MECHANISMS, 2009, 2 (3-4) : 139 - 156
[43] The telomeric protein TRF2 restrains a cell-extrinsic pathway by which cancer cells are eliminated by natural killer (NK) cells
Cherfils-Vicini, J.
Biroccio, A.
Pinte, S.
Bauwens, S.
Cognet, C.
Peeper, D.
Smyth, M. J.
Londono-Vallejo, A.
Picco, V.
Pages, G.
Scoazec, J. Y.
Stoppacciaro, A.
Leonetti, C.
Vivier, E.
Gilson, E.
IMMUNOLOGY, 2012, 137 : 621 - 621
[44] Activation of p21 following DNA damage transcriptionally controlled by a telomeric shelterin protein TRF2 in a telomere-length dependent fashion
Chowdhury, Shantanu
FASEB JOURNAL, 2016, 30
[45] The telomeric protein TRF2 is critical for the protection of A549 cells from both telomere erosion and DNA double-strand breaks driven by salvicine
Zhang, Yong-Wei
Zhang, Zhi-Xiang
Miao, Ze-Hong
Ding, Jian
MOLECULAR PHARMACOLOGY, 2008, 73 (03) : 824 - 832
[46] Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas
Matsutani, N
Yokozaki, H
Tahara, E
Tahara, H
Kuniyasu, H
Haruma, K
Chayama, K
Yasui, W
Tahara, E
INTERNATIONAL JOURNAL OF ONCOLOGY, 2001, 19 (03) : 507 - 512
[47] G-quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3′ telomeric overhang in cancer cells
Tahara, H
Shin-ya, K
Seimiya, H
Yamada, H
Tsuruo, T
Ide, T
ONCOGENE, 2006, 25 (13) : 1955 - 1966
[48] G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3′ telomeric overhang in cancer cells
H Tahara
K Shin-ya
H Seimiya
H Yamada
T Tsuruo
T Ide
Oncogene, 2006, 25 : 1955 - 1966
[49] The telomere capping protein telomeric repeat-binding factor-2 (TRF2) mediates normal cardiac muscle cell survival and protects against doxorubicin-induced cardiomyopathy
Wang, SC
Prahash, A
Oh, H
Sano, M
Xie, M
Taffet, GE
JOURNAL OF CARDIAC FAILURE, 2004, 10 (04) : S17 - S17
[50] Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex
Ran, Xu
Liu, Liu
Yang, Chao-Yie
Lu, Jianfeng
Chen, Yong
Lei, Ming
Wang, Shaomeng
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (01) : 328 - 334

← 1 2 3 4 5 →