NMR studies of telomeric nucleoprotein complexes involving the Myb-like domain of the human telomeric protein TRF2

被引：3

作者：

Bilbille, Y ^{[1
]}

Paquet, F ^{[1
]}

Meudal, H ^{[1
]}

Giraud-Panis, MJ ^{[1
]}

Lancelot, G ^{[1
]}

机构：

[1] CNRS, UPR 4301, Ctr Biophys Mol, F-45071 Orleans 2, France

来源：

COMPTES RENDUS CHIMIE | 2006年 / 9卷 / 3-4期

关键词：

NMR structure; telomere; DNA; quadruplex; Myb-TRF2 DNA binding protein;

D O I：

10.1016/j.crci.2005.06.016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to study the binding of the Myb-like domain of the human telomeric protein TRF2 (Myb-TRF2) with different structural components of the t-loop model, we report NMR studies of the binding of Myb-TRF2 protein with two repeats human telomeric DNA under three conformations. Our results showed that Myb-TRF2 binds to the duplex and even to the quadruplex and the random coil G-rich strand. The solution structure of Myb-TRF2 reported here looks like Myb-TRF1 suggesting similar DNA binding mode. As a matter of fact, we have shown that its binding to the human telomeric duplex presents great similarities with this of Myb-TRF1.

引用

页码：452 / 458

页数：7

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