Regulation of the APC and the exit from mitosis

被引:301
|
作者
Morgan, DO [1 ]
机构
[1] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
关键词
D O I
10.1038/10039
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The events of late mitosis, from sister-chromatid separation to cytokinesis, are governed by the anaphase-promoting complex (APC), a multisubunit assembly that triggers the ubiquitin-dependent proteloysis of key regulatory proteins. An intricate regulatory network governs Ape activity and helps to ensure that late mitotic events are properly timed and coordinated.
引用
收藏
页码:E47 / E53
页数:7
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