Catalyst Free Synthesis of Bis(Indolyl)Methanes and 3,3-Bis(Indolyl)oxindoles in Aqueous Ethyl Lactate

被引：29
|
作者：
Gao, Ge [1 ]
Han, Yi [1 ]
Zhang, Zhan-Hui [1 ]
机构：
[1] Hebei Normal Univ, Natl Demonstrat Ctr Expt Chem Educ, Coll Chem & Mat Sci, Shijiazhuang 050024, Hebei, Peoples R China
来源：
CHEMISTRYSELECT | 2017年 / 2卷 / 35期
基金：
中国国家自然科学基金;
关键词：
Bis(indolyl)methanes; 3,3-Bis(indolyl)oxindoles; Ethyl lactate; Indoles; Ultrasound;
D O I：
10.1002/slct.201702326
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient and environmentally friendly approach has been reported for the synthesis of bis(indolyl)methanes and 3,3-bis(indolyl)oxindoles by reacting of indoles with aldehydes or isatins in water-ethyl lactate under ultrasound irradiation. This protocol presents the benefits of catalyst-free, operational simplicity, short reaction time, high product yield, broad substrate scope and applicability for large-scale synthesis.
引用
收藏
页码：11561 / 11564
页数：4
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