Catalyst Free Synthesis of Bis(Indolyl)Methanes and 3,3-Bis(Indolyl)oxindoles in Aqueous Ethyl Lactate

被引：29
|
作者：
Gao, Ge [1 ]
Han, Yi [1 ]
Zhang, Zhan-Hui [1 ]
机构：
[1] Hebei Normal Univ, Natl Demonstrat Ctr Expt Chem Educ, Coll Chem & Mat Sci, Shijiazhuang 050024, Hebei, Peoples R China
来源：
CHEMISTRYSELECT | 2017年 / 2卷 / 35期
基金：
中国国家自然科学基金;
关键词：
Bis(indolyl)methanes; 3,3-Bis(indolyl)oxindoles; Ethyl lactate; Indoles; Ultrasound;
D O I：
10.1002/slct.201702326
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient and environmentally friendly approach has been reported for the synthesis of bis(indolyl)methanes and 3,3-bis(indolyl)oxindoles by reacting of indoles with aldehydes or isatins in water-ethyl lactate under ultrasound irradiation. This protocol presents the benefits of catalyst-free, operational simplicity, short reaction time, high product yield, broad substrate scope and applicability for large-scale synthesis.
引用
收藏
页码：11561 / 11564
页数：4
相关论文
共 50 条
  • [31] Inclusion Complexation of Phenoxyaliphatic Acid Derivatives of 3,3′-bis(indolyl)methanes with β-Cyclodextrin
    A. Antony Muthu Prabhu
    G. S. Suresh Kumar
    Journal of Fluorescence, 2014, 24 : 925 - 931
  • [32] Inclusion Complexation of Phenoxyaliphatic Acid Derivatives of 3,3'-bis(indolyl)methanes with β-Cyclodextrin
    Prabhu, A. Antony Muthu
    Kumar, G. S. Suresh
    JOURNAL OF FLUORESCENCE, 2014, 24 (03) : 925 - 931
  • [33] Droplet-based continuous flow synthesis of biologically active Bis (indolyl)methanes and Tris(indolyl)methanes
    Nam, Su Min
    Jang, Yea Seul
    Son, Go Eun
    Song, Chan Ho
    In, Insik
    Park, Chan Pil
    TETRAHEDRON LETTERS, 2020, 61 (32)
  • [34] Bis(cyclopentadienyl)zirconium dichloride for alkylation of heteroaromatics and synthesis of bis(indolyl)methanes
    Kantam, ML
    Aziz, K
    Likhar, PR
    CATALYSIS LETTERS, 2004, 98 (2-3) : 117 - 121
  • [35] In situ generation of Iron(III) dodecyl sulfate as Lewis acid-surfactant catalyst for synthesis of bis-indolyl, tris-indolyl, Di(bis-indolyl), Tri(bis-indolyl), tetra(bis-indolyl)methanes and 3-alkylated indole compounds in water
    Veisi, Hojat
    Maleki, Behrooz
    Eshbala, Fereshteh Hosseini
    Veisi, Hamed
    Masti, Ramin
    Ashrafi, Samaneh Sedigh
    Baghayeri, Mehdi
    RSC ADVANCES, 2014, 4 (58) : 30683 - 30688
  • [36] First Synthesis of Bis(di(indolyl)aryl)methanes From Bis(salicylaldehydes)
    Bakthadoss, Manickam
    Devaraj, Anthonisamy
    Srinivasan, Jayakumar
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 52 (02) : 418 - 424
  • [37] Bis(cyclopentadienyl)zirconium Dichloride for Alkylation of Heteroaromatics and Synthesis of Bis(indolyl)methanes
    M. Lakshmi Kantam
    Khathija Aziz
    Pravin R. Likhar
    Catalysis Letters, 2004, 98 : 117 - 121
  • [38] Ruthenium-exchanged montmorillonite as an efficient and reusable catalyst for the synthesis of bis(indolyl)methanes
    Takbiri, Sam
    Hafshejani, Mahmood Tavakoli
    Shirini, Farhad
    Vari, Zahra
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2024, 21 (07) : 1929 - 1935
  • [39] An effective green and ecofriendly catalyst for synthesis of bis(indolyl)methanes as promising antimicrobial agents
    Nemallapudi, Bakthavatchala Reddy
    Zyryanov, Grigory V.
    Avula, Balakrishna
    Guda, Mallikarjuna Reddy
    Gundala, Sravya
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (12) : 3324 - 3332
  • [40] Surfactant-assisted synthesis of bis(indolyl)methanes in water
    Eskandar Kolvari
    Mohammad Ali Zolfigol
    Hoda Banary
    Chinese Chemical Letters, 2011, 22 (11) : 1305 - 1308
12345